International union of pharmacology. LX. Retinoic acid receptors

Pierre Germain; Pierre Chambon; Gregor Eichele; Ronald M. Evans; Mitchell A. Lazar; Mark Leid; Angel R. De Lera; Reuben Lotan; David J. Mangelsdorf; Hinrich Gronemeyer

doi:10.1124/pr.58.4.4

International union of pharmacology. LX. Retinoic acid receptors

Pierre Germain, Pierre Chambon, Gregor Eichele, Ronald M. Evans, Mitchell A. Lazar, Mark Leid, Angel R. De Lera, Reuben Lotan, David J. Mangelsdorf, Hinrich Gronemeyer

Research output: Contribution to journal › Review article › peer-review

340 Scopus citations

Abstract

Retinoid is a term for compounds that bind to and activate retinoic acid receptors (RARα, RARβ, and RARγ), members of the nuclear hormone receptor superfamily. The most important endogenous retinoid is all-trans-retinoic acid. Retinoids regulate a wide variety of essential biological processes, such as vertebrate embryonic morphogenesis and organogenesis, cell growth arrest, differentiation and apoptosis, and homeostasis, as well as their disorders. This review summarizes the considerable amount of knowledge generated on these receptors.

Original language	English (US)
Pages (from-to)	712-725
Number of pages	14
Journal	Pharmacological reviews
Volume	58
Issue number	4
DOIs	https://doi.org/10.1124/pr.58.4.4
State	Published - Dec 2006

ASJC Scopus subject areas

Molecular Medicine
Pharmacology

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10.1124/pr.58.4.4

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abstract = "Retinoid is a term for compounds that bind to and activate retinoic acid receptors (RARα, RARβ, and RARγ), members of the nuclear hormone receptor superfamily. The most important endogenous retinoid is all-trans-retinoic acid. Retinoids regulate a wide variety of essential biological processes, such as vertebrate embryonic morphogenesis and organogenesis, cell growth arrest, differentiation and apoptosis, and homeostasis, as well as their disorders. This review summarizes the considerable amount of knowledge generated on these receptors.",

author = "Pierre Germain and Pierre Chambon and Gregor Eichele and Evans, {Ronald M.} and Lazar, {Mitchell A.} and Mark Leid and {De Lera}, {Angel R.} and Reuben Lotan and Mangelsdorf, {David J.} and Hinrich Gronemeyer",

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AU - Germain, Pierre

AU - Chambon, Pierre

AU - Eichele, Gregor

AU - Evans, Ronald M.

AU - Lazar, Mitchell A.

AU - Leid, Mark

AU - De Lera, Angel R.

AU - Lotan, Reuben

AU - Mangelsdorf, David J.

AU - Gronemeyer, Hinrich

PY - 2006/12

Y1 - 2006/12

N2 - Retinoid is a term for compounds that bind to and activate retinoic acid receptors (RARα, RARβ, and RARγ), members of the nuclear hormone receptor superfamily. The most important endogenous retinoid is all-trans-retinoic acid. Retinoids regulate a wide variety of essential biological processes, such as vertebrate embryonic morphogenesis and organogenesis, cell growth arrest, differentiation and apoptosis, and homeostasis, as well as their disorders. This review summarizes the considerable amount of knowledge generated on these receptors.

AB - Retinoid is a term for compounds that bind to and activate retinoic acid receptors (RARα, RARβ, and RARγ), members of the nuclear hormone receptor superfamily. The most important endogenous retinoid is all-trans-retinoic acid. Retinoids regulate a wide variety of essential biological processes, such as vertebrate embryonic morphogenesis and organogenesis, cell growth arrest, differentiation and apoptosis, and homeostasis, as well as their disorders. This review summarizes the considerable amount of knowledge generated on these receptors.

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International union of pharmacology. LX. Retinoic acid receptors

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