TY - JOUR
T1 - Interleukin-1 in human skin
T2 - Dysregulation in psoriasis
AU - Cooper, Kevin D.
AU - Hammerberg, Craig
AU - Baadsgaard, Ole
AU - Elder, J. T.
AU - Chan, Lawrence S.
AU - Taylor, Robert S.
AU - Voorhees, John J.
AU - Fisher, Gary
PY - 1990/11
Y1 - 1990/11
N2 - Cytokine dysregulation is an attractive concept to explain many of the observed abnormalities in psoriasis. IL-1, in particular, can potentiate immune cellular activation, activate fibroblasts, and increase endothelial cell adhesiveness to leukocytes. Here, we review IL-1 regulation in normal and psoriatic skin in vivo in relation to normal skin and cultured keratinocytes. Contrary to expectations, IL-1 functional activity in psoriatic lesions is reduced, not increased, relative to normal skin. The reduction is attributable to the presence of IL-1 inhibitors, reduced IL-lα levels, and an IL-1β that lacked function in T-cell assays. IL-1β protein is actually significantly increased in non-functionality remains unclear. Unlike cultured keratinocytes, which accumulate large, inactive IL-1β precursors, both normal and psoriatic skin process IL-1β to a mature form. Novel mechanisms of post-translational processing by epidermis in vivo may generate a novel form of IL-1β with unknown functions. The marked abnormalities of IL-1 regulation in psoriatic skin suggest that this molecule may be important in normal skin homeostasis.
AB - Cytokine dysregulation is an attractive concept to explain many of the observed abnormalities in psoriasis. IL-1, in particular, can potentiate immune cellular activation, activate fibroblasts, and increase endothelial cell adhesiveness to leukocytes. Here, we review IL-1 regulation in normal and psoriatic skin in vivo in relation to normal skin and cultured keratinocytes. Contrary to expectations, IL-1 functional activity in psoriatic lesions is reduced, not increased, relative to normal skin. The reduction is attributable to the presence of IL-1 inhibitors, reduced IL-lα levels, and an IL-1β that lacked function in T-cell assays. IL-1β protein is actually significantly increased in non-functionality remains unclear. Unlike cultured keratinocytes, which accumulate large, inactive IL-1β precursors, both normal and psoriatic skin process IL-1β to a mature form. Novel mechanisms of post-translational processing by epidermis in vivo may generate a novel form of IL-1β with unknown functions. The marked abnormalities of IL-1 regulation in psoriatic skin suggest that this molecule may be important in normal skin homeostasis.
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U2 - 10.1111/1523-1747.ep12505698
DO - 10.1111/1523-1747.ep12505698
M3 - Article
C2 - 16788624
AN - SCOPUS:0025225424
SN - 0022-202X
VL - 95
SP - S24-S26
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 5
ER -