Interim ¹⁸F-FDG-PET/CT during chemo-radiotherapy in the management of oesophageal cancer patients. A systematic review

Oesophageal cancer is an aggressive disease. The possibility to early stratify patients as responsive and non-responsive with a non-invasive method is extremely appealing. The uptake of Fluorodeoxyglucose (¹⁸F-FDG) in tumours, provided by positron emission tomography (PET) images, has been proved to be useful to assess the initial staging of the disease, recurrence, and response to chemotherapy and chemo-radiotherapy (CRT). In the last years, efforts have been focused on the possibility to use ad interim ¹⁸F-FDG-PET/CT (PET_int) to evaluate response during radiation therapy. However, controversial findings have been reported, although some relevant results would support its use for individual therapeutic decision. The present review assembles the comprehensive literature of the last decade to evaluate whether and in which cases PET_int may offer predictive potential in oesophageal cancer. All the analysed studies (13 studies, 697 patients) denoted PET_int as a challenging examination for early assessment of outcomes during CRT. In particular, 8 studies advocated the predictivity of PET_int, whilst 5 did not find any correlation between the interim variation of PET parameters and the pathological complete response and/or the clinical outcome. The reasons that possibly have caused contradictions among the studies demand further research with prospective and uniform protocols and methods of analysis to assess the predictive and prognostic value of PET_int in oesophageal cancer.