TY - JOUR
T1 - Interdisciplinary Models for Research and Clinical Endeavors in Genomic Medicine
T2 - A Scientific Statement From the American Heart Association
AU - American Heart Association Council on Genomic and Precision Medicine; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Radiology and Intervention; Council on Peripheral Vascular Diseas
AU - Musunuru, Kiran
AU - Arora, Pankaj
AU - Cooke, John P.
AU - Ferguson, Jane F.
AU - Hershberger, Ray E.
AU - Hickey, Kathleen T.
AU - Lee, Jin Moo
AU - Lima, João A.C.
AU - Loscalzo, Joseph
AU - Pereira, Naveen L.
AU - Russell, Mark W.
AU - Shah, Svati H.
AU - Sheikh, Farah
AU - Wang, Thomas J.
AU - MacRae, Calum A.
N1 - Publisher Copyright:
© 2018 American Heart Association, Inc.
PY - 2018/6/1
Y1 - 2018/6/1
N2 - The completion of the Human Genome Project has unleashed a wealth of human genomics information, but it remains unclear how best to implement this information for the benefit of patients. The standard approach of biomedical research, with researchers pursuing advances in knowledge in the laboratory and, separately, clinicians translating research findings into the clinic as much as decades later, will need to give way to new interdisciplinary models for research in genomic medicine. These models should include scientists and clinicians actively working as teams to study patients and populations recruited in clinical settings and communities to make genomics discoveries-through the combined efforts of data scientists, clinical researchers, epidemiologists, and basic scientists-and to rapidly apply these discoveries in the clinic for the prediction, prevention, diagnosis, prognosis, and treatment of cardiovascular diseases and stroke. The highly publicized US Precision Medicine Initiative, also known as All of Us, is a large-scale program funded by the US National Institutes of Health that will energize these efforts, but several ongoing studies such as the UK Biobank Initiative; the Million Veteran Program; the Electronic Medical Records and Genomics Network; the Kaiser Permanente Research Program on Genes, Environment and Health; and the DiscovEHR collaboration are already providing exemplary models of this kind of interdisciplinary work. In this statement, we outline the opportunities and challenges in broadly implementing new interdisciplinary models in academic medical centers and community settings and bringing the promise of genomics to fruition.
AB - The completion of the Human Genome Project has unleashed a wealth of human genomics information, but it remains unclear how best to implement this information for the benefit of patients. The standard approach of biomedical research, with researchers pursuing advances in knowledge in the laboratory and, separately, clinicians translating research findings into the clinic as much as decades later, will need to give way to new interdisciplinary models for research in genomic medicine. These models should include scientists and clinicians actively working as teams to study patients and populations recruited in clinical settings and communities to make genomics discoveries-through the combined efforts of data scientists, clinical researchers, epidemiologists, and basic scientists-and to rapidly apply these discoveries in the clinic for the prediction, prevention, diagnosis, prognosis, and treatment of cardiovascular diseases and stroke. The highly publicized US Precision Medicine Initiative, also known as All of Us, is a large-scale program funded by the US National Institutes of Health that will energize these efforts, but several ongoing studies such as the UK Biobank Initiative; the Million Veteran Program; the Electronic Medical Records and Genomics Network; the Kaiser Permanente Research Program on Genes, Environment and Health; and the DiscovEHR collaboration are already providing exemplary models of this kind of interdisciplinary work. In this statement, we outline the opportunities and challenges in broadly implementing new interdisciplinary models in academic medical centers and community settings and bringing the promise of genomics to fruition.
KW - AHA Scientific Statements
KW - genomics
UR - http://www.scopus.com/inward/record.url?scp=85065012848&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065012848&partnerID=8YFLogxK
U2 - 10.1161/HCG.0000000000000046
DO - 10.1161/HCG.0000000000000046
M3 - Review article
C2 - 29844141
AN - SCOPUS:85065012848
SN - 1942-325X
VL - 11
SP - e000046
JO - Circulation. Genomic and precision medicine
JF - Circulation. Genomic and precision medicine
IS - 6
ER -