Interaction of phencyclidine with drugs affecting cholinergic neurotransmission

P. M. Adams

doi:10.1016/0028-3908(80)90130-6

Interaction of phencyclidine with drugs affecting cholinergic neurotransmission

P. M. Adams

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Locomotor activity induced by phencyclidine was studied in combination with a number of cholinergic-acting drugs (atropine, methyl atropine and physostigmine). Atropine, but not the methyl form. potentiated the phencyclidne-induced activity. Physostigmine blocked the phencyclidine-induced activity at all dosages studied. These findings support the involvement of cholinergic receptors in the effects of phencyclidine and address several clinical pharmacology considerations in the treatment of phencyclidine toxicity.

Original language	English (US)
Pages (from-to)	151-153
Number of pages	3
Journal	Neuropharmacology
Volume	19
Issue number	2
DOIs	https://doi.org/10.1016/0028-3908(80)90130-6
State	Published - Feb 1980

ASJC Scopus subject areas

Pharmacology
Cellular and Molecular Neuroscience

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AB - Locomotor activity induced by phencyclidine was studied in combination with a number of cholinergic-acting drugs (atropine, methyl atropine and physostigmine). Atropine, but not the methyl form. potentiated the phencyclidne-induced activity. Physostigmine blocked the phencyclidine-induced activity at all dosages studied. These findings support the involvement of cholinergic receptors in the effects of phencyclidine and address several clinical pharmacology considerations in the treatment of phencyclidine toxicity.

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Interaction of phencyclidine with drugs affecting cholinergic neurotransmission

Abstract

ASJC Scopus subject areas

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