Inter-kingdom signaling: chemical language between bacteria and host

Alline R. Pacheco, Vanessa Sperandio

Research output: Contribution to journalReview articlepeer-review

138 Scopus citations


Chemical communication between cells ensures coordination of behavior. In prokaryotes, this chemical communication is usually referred to as quorum sensing, while eukaryotic cells signal through hormones. In the past years, a growing number of reports have shown that bacterial quorum sensing signals, called autoinducers, signal to eukaryotic cells, mimicking hormones. Conversely, host hormones can signal to bacterial cells through converging pathways to autoinducer signaling. This inter-kingdom signaling mediates symbiotic and pathogenic relationships between bacteria, mammalian and plant hosts.

Original languageEnglish (US)
Pages (from-to)192-198
Number of pages7
JournalCurrent Opinion in Microbiology
Issue number2
StatePublished - Apr 2009

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases


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