Integrated magnetic resonance imaging and phosphorus spectroscopy of soft tissue tumors

M. A. Shinkwin, R. E. Lenkinski, J. M. Daly, M. B. Zlatkin, T. S. Frank, G. A. Holland, H. Y. Kressel

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Eighteen patients with soft tissue masses underwent integrated magnetic resonance imaging (MRI) and phosphorus spectroscopy (31P‐MRS) to evaluate benign and malignant tumor morphology and metabolism. Spectra from soft tissue tumors had a significantly higher proportion of phosphate in the low‐energy portion of the 31P spectrum (P < 0.001) with a concomitant decrease in phosphocreatine (P < 0.01) compared with 31P spectra from normal muscle. Malignant tumors had a mean pH of 7.35 ± 0.13 which was greater than that of muscle tissue with a mean pH of 7.08 ± 0.07 (P < 0.001). All tumors had greater relative levels of phosphomonoesters, inorganic phosphate, and phosphodiesters compared with those in muscle tissue but considerable variability among tumors was noted due to tumor size, extent of tumor necrosis, and muscle contamination. Integrated MRI/MRS studies are necessary to provide exact localization of the tumor and a more correct interpretation of the 31P‐MRS data.

Original languageEnglish (US)
Pages (from-to)1849-1858
Number of pages10
Issue number7
StatePublished - Apr 1 1991

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Integrated magnetic resonance imaging and phosphorus spectroscopy of soft tissue tumors'. Together they form a unique fingerprint.

Cite this