Insights into the Irritating Mechanisms of TRPA1 Revealed by Cryo-EM

Michael Fine; Xiaochun Li

doi:10.1016/j.neuron.2020.12.017

Insights into the Irritating Mechanisms of TRPA1 Revealed by Cryo-EM

Research output: Contribution to journal › Article › peer-review

Abstract

TRPA1 is a promising target for the development of novel treatments for chronic pain. In this issue of Neuron, Liu et al. (2021) report a novel non-covalent TRPA1-biased agonist, GNE551, revealing a unique binding pocket by cryo-EM and activation properties that pave a path toward new avenues in the treatment of chronic pain.

Original language	English (US)
Pages (from-to)	194-196
Number of pages	3
Journal	Neuron
Volume	109
Issue number	2
DOIs	https://doi.org/10.1016/j.neuron.2020.12.017
State	Published - Jan 20 2021

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neuron.2020.12.017

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title = "Insights into the Irritating Mechanisms of TRPA1 Revealed by Cryo-EM",

abstract = "TRPA1 is a promising target for the development of novel treatments for chronic pain. In this issue of Neuron, Liu et al. (2021) report a novel non-covalent TRPA1-biased agonist, GNE551, revealing a unique binding pocket by cryo-EM and activation properties that pave a path toward new avenues in the treatment of chronic pain.",

author = "Michael Fine and Xiaochun Li",

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Insights into the Irritating Mechanisms of TRPA1 Revealed by Cryo-EM

Abstract

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