Innate immunity and aging

Christian R. Gomez, Vanessa Nomellini, Douglas E. Faunce, Elizabeth J. Kovacs

Research output: Contribution to journalShort surveypeer-review

242 Scopus citations


Advanced age is associated with defects in all of the cells of the innate immune system, including numbers, function, and early stages of activation. This review, presents the current state of the field on the impact of age on the innate immune system. The analysis of the literature suggests that a dysfunctional innate immune system is a contributing factor to aberrant outcomes after injury or infection and to the development of many of the diseases observed in the elderly. Gaining an understanding of the nature of the defects in innate immune cells may allow the development of therapeutic strategies aimed to restore innate immune function in aged individuals.

Original languageEnglish (US)
Pages (from-to)718-728
Number of pages11
JournalExperimental Gerontology
Issue number8
StatePublished - Aug 2008
Externally publishedYes


  • Age
  • Eosinophils
  • Macrophages
  • Mast cells
  • Neutrophils
  • NK
  • NK-T

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology


Dive into the research topics of 'Innate immunity and aging'. Together they form a unique fingerprint.

Cite this