Innate immunity and aging

Christian R. Gomez; Vanessa Nomellini; Douglas E. Faunce; Elizabeth J. Kovacs

doi:10.1016/j.exger.2008.05.016

Innate immunity and aging

Christian R. Gomez, Vanessa Nomellini, Douglas E. Faunce, Elizabeth J. Kovacs

Research output: Contribution to journal › Short survey › peer-review

257 Scopus citations

Abstract

Advanced age is associated with defects in all of the cells of the innate immune system, including numbers, function, and early stages of activation. This review, presents the current state of the field on the impact of age on the innate immune system. The analysis of the literature suggests that a dysfunctional innate immune system is a contributing factor to aberrant outcomes after injury or infection and to the development of many of the diseases observed in the elderly. Gaining an understanding of the nature of the defects in innate immune cells may allow the development of therapeutic strategies aimed to restore innate immune function in aged individuals.

Original language	English (US)
Pages (from-to)	718-728
Number of pages	11
Journal	Experimental Gerontology
Volume	43
Issue number	8
DOIs	https://doi.org/10.1016/j.exger.2008.05.016
State	Published - Aug 2008
Externally published	Yes

Keywords

Age
Eosinophils
Macrophages
Mast cells
NK
NK-T
Neutrophils

ASJC Scopus subject areas

Biochemistry
Aging
Molecular Biology
Genetics
Endocrinology
Cell Biology

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10.1016/j.exger.2008.05.016

Cite this

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title = "Innate immunity and aging",

abstract = "Advanced age is associated with defects in all of the cells of the innate immune system, including numbers, function, and early stages of activation. This review, presents the current state of the field on the impact of age on the innate immune system. The analysis of the literature suggests that a dysfunctional innate immune system is a contributing factor to aberrant outcomes after injury or infection and to the development of many of the diseases observed in the elderly. Gaining an understanding of the nature of the defects in innate immune cells may allow the development of therapeutic strategies aimed to restore innate immune function in aged individuals.",

keywords = "Age, Eosinophils, Macrophages, Mast cells, NK, NK-T, Neutrophils",

author = "Gomez, {Christian R.} and Vanessa Nomellini and Faunce, {Douglas E.} and Kovacs, {Elizabeth J.}",

note = "Funding Information: This work was supported by the National Institutes of Health R01 AG018859 (EJK), NIH R01 AI056108 (DEF), F30 AG029724 (VN), American Federation for Aging Research (AFAR) (DEF), Illinois Excellence in Academic Medicine Award (EJK, DEF), and Ralph and Marian C. Falk Research Trust (EJK, DEF). ",

year = "2008",

month = aug,

doi = "10.1016/j.exger.2008.05.016",

language = "English (US)",

volume = "43",

pages = "718--728",

journal = "Experimental Gerontology",

issn = "0531-5565",

publisher = "Elsevier Inc.",

number = "8",

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TY - JOUR

T1 - Innate immunity and aging

AU - Gomez, Christian R.

AU - Nomellini, Vanessa

AU - Faunce, Douglas E.

AU - Kovacs, Elizabeth J.

N1 - Funding Information: This work was supported by the National Institutes of Health R01 AG018859 (EJK), NIH R01 AI056108 (DEF), F30 AG029724 (VN), American Federation for Aging Research (AFAR) (DEF), Illinois Excellence in Academic Medicine Award (EJK, DEF), and Ralph and Marian C. Falk Research Trust (EJK, DEF).

PY - 2008/8

Y1 - 2008/8

N2 - Advanced age is associated with defects in all of the cells of the innate immune system, including numbers, function, and early stages of activation. This review, presents the current state of the field on the impact of age on the innate immune system. The analysis of the literature suggests that a dysfunctional innate immune system is a contributing factor to aberrant outcomes after injury or infection and to the development of many of the diseases observed in the elderly. Gaining an understanding of the nature of the defects in innate immune cells may allow the development of therapeutic strategies aimed to restore innate immune function in aged individuals.

AB - Advanced age is associated with defects in all of the cells of the innate immune system, including numbers, function, and early stages of activation. This review, presents the current state of the field on the impact of age on the innate immune system. The analysis of the literature suggests that a dysfunctional innate immune system is a contributing factor to aberrant outcomes after injury or infection and to the development of many of the diseases observed in the elderly. Gaining an understanding of the nature of the defects in innate immune cells may allow the development of therapeutic strategies aimed to restore innate immune function in aged individuals.

KW - Age

KW - Eosinophils

KW - Macrophages

KW - Mast cells

KW - NK

KW - NK-T

KW - Neutrophils

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DO - 10.1016/j.exger.2008.05.016

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SN - 0531-5565

VL - 43

SP - 718

EP - 728

JO - Experimental Gerontology

JF - Experimental Gerontology

IS - 8

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Innate immunity and aging

Abstract

Keywords

ASJC Scopus subject areas

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