TY - JOUR
T1 - Innate control of adaptive immunity
T2 - Beyond the three-signal paradigm
AU - Jain, Aakanksha
AU - Pasare, Chandrashekhar
N1 - Funding Information:
This work was supported by National Institutes of Health Grants AI123176, AI113125, and AI115420 (to C.P.).
Publisher Copyright:
© 2017 by The American Association of Immunologists, Inc.
PY - 2017/5/15
Y1 - 2017/5/15
N2 - Activation of cells in the adaptive immune system is a highly orchestrated process dictated by multiples cues from the innate immune system. Although the fundamental principles of innate control of adaptive immunity are well established, it is not fully understood how innate cells integrate qualitative pathogenic information to generate tailored protective adaptive immune responses. In this review, we discuss complexities involved in the innate control of adaptive immunity that extend beyond TCR engagement, costimulation, and priming cytokine production but are critical for the generation of protective T cell immunity.
AB - Activation of cells in the adaptive immune system is a highly orchestrated process dictated by multiples cues from the innate immune system. Although the fundamental principles of innate control of adaptive immunity are well established, it is not fully understood how innate cells integrate qualitative pathogenic information to generate tailored protective adaptive immune responses. In this review, we discuss complexities involved in the innate control of adaptive immunity that extend beyond TCR engagement, costimulation, and priming cytokine production but are critical for the generation of protective T cell immunity.
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U2 - 10.4049/jimmunol.1602000
DO - 10.4049/jimmunol.1602000
M3 - Review article
C2 - 28483987
AN - SCOPUS:85019716261
SN - 0022-1767
VL - 198
SP - 3791
EP - 3800
JO - Journal of Immunology
JF - Journal of Immunology
IS - 10
ER -