Inhibition of transforming growth factor-β2 expression with phosphorothioate antisense oligonucleotides in U937 cells

Zhong Jian Shen; Sang Kook Kim; Young Sup Lee; Jong Won Lee; Byung Jo Moon

doi:10.1016/S0960-894X(98)00675-1

Inhibition of transforming growth factor-β2 expression with phosphorothioate antisense oligonucleotides in U937 cells

Zhong Jian Shen, Sang Kook Kim, Young Sup Lee, Jong Won Lee, Byung Jo Moon

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Four types of phosphorothioate antisense oligonucleotides for transforming growth factor-β2 were synthesized and tested for their antisense activity in U937 cells. The full-length phosphorothioate modified antisense analogues exhibited the highest inhibitory effects on the transforming growth factor-β2 expression in U937 cells.

Original language	English (US)
Pages (from-to)	13-18
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	9
Issue number	1
DOIs	https://doi.org/10.1016/S0960-894X(98)00675-1
State	Published - Jan 1999

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(98)00675-1

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title = "Inhibition of transforming growth factor-β2 expression with phosphorothioate antisense oligonucleotides in U937 cells",

abstract = "Four types of phosphorothioate antisense oligonucleotides for transforming growth factor-β2 were synthesized and tested for their antisense activity in U937 cells. The full-length phosphorothioate modified antisense analogues exhibited the highest inhibitory effects on the transforming growth factor-β2 expression in U937 cells.",

author = "Shen, {Zhong Jian} and Kim, {Sang Kook} and Lee, {Young Sup} and Lee, {Jong Won} and Moon, {Byung Jo}",

note = "Funding Information: Acknowledgment. This work was supported by the Korea Science and Engineering Foundation through the Center for Biofunctional Molecules.",

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AU - Shen, Zhong Jian

AU - Kim, Sang Kook

AU - Lee, Young Sup

AU - Lee, Jong Won

AU - Moon, Byung Jo

N1 - Funding Information: Acknowledgment. This work was supported by the Korea Science and Engineering Foundation through the Center for Biofunctional Molecules.

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AB - Four types of phosphorothioate antisense oligonucleotides for transforming growth factor-β2 were synthesized and tested for their antisense activity in U937 cells. The full-length phosphorothioate modified antisense analogues exhibited the highest inhibitory effects on the transforming growth factor-β2 expression in U937 cells.

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Inhibition of transforming growth factor-β2 expression with phosphorothioate antisense oligonucleotides in U937 cells

Abstract

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