Inhibiting transcription of chromosomal DNA using antigene RNAs.

Bethany A. Janowski; David R. Corey

doi:10.1093/nass/49.1.367

Inhibiting transcription of chromosomal DNA using antigene RNAs.

Bethany A. Janowski, David R. Corey

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Transcription start sites are critical switches for converting recognition of chromosomal DNA into synthesis of RNA. We report that antigene peptide nucleic acid (agPNA) oligomers or antigene RNA (agRNA) duplexes can target transcription start sites and block gene expression. Our data suggest that chromosomal DNA within cells is readily accessible to recognition by synthetic agents. agPNAs and agRNAs will be useful tools for silencing gene expression and will provide insights into natural mechanisms for controlling transcription.

Original language	English (US)
Pages (from-to)	367-368
Number of pages	2
Journal	Nucleic acids symposium series (2004)
Issue number	49
DOIs	https://doi.org/10.1093/nass/49.1.367
State	Published - 2005

ASJC Scopus subject areas

General Medicine

Access to Document

10.1093/nass/49.1.367

Cite this

@article{3887d391aaea4278a711752bba58039a,

title = "Inhibiting transcription of chromosomal DNA using antigene RNAs.",

abstract = "Transcription start sites are critical switches for converting recognition of chromosomal DNA into synthesis of RNA. We report that antigene peptide nucleic acid (agPNA) oligomers or antigene RNA (agRNA) duplexes can target transcription start sites and block gene expression. Our data suggest that chromosomal DNA within cells is readily accessible to recognition by synthetic agents. agPNAs and agRNAs will be useful tools for silencing gene expression and will provide insights into natural mechanisms for controlling transcription.",

author = "Janowski, {Bethany A.} and Corey, {David R.}",

year = "2005",

doi = "10.1093/nass/49.1.367",

language = "English (US)",

pages = "367--368",

journal = "Nucleic acids symposium series (2004)",

issn = "1746-8272",

publisher = "Oxford University Press",

number = "49",

}

TY - JOUR

T1 - Inhibiting transcription of chromosomal DNA using antigene RNAs.

AU - Janowski, Bethany A.

AU - Corey, David R.

PY - 2005

Y1 - 2005

N2 - Transcription start sites are critical switches for converting recognition of chromosomal DNA into synthesis of RNA. We report that antigene peptide nucleic acid (agPNA) oligomers or antigene RNA (agRNA) duplexes can target transcription start sites and block gene expression. Our data suggest that chromosomal DNA within cells is readily accessible to recognition by synthetic agents. agPNAs and agRNAs will be useful tools for silencing gene expression and will provide insights into natural mechanisms for controlling transcription.

AB - Transcription start sites are critical switches for converting recognition of chromosomal DNA into synthesis of RNA. We report that antigene peptide nucleic acid (agPNA) oligomers or antigene RNA (agRNA) duplexes can target transcription start sites and block gene expression. Our data suggest that chromosomal DNA within cells is readily accessible to recognition by synthetic agents. agPNAs and agRNAs will be useful tools for silencing gene expression and will provide insights into natural mechanisms for controlling transcription.

UR - http://www.scopus.com/inward/record.url?scp=34447101429&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34447101429&partnerID=8YFLogxK

U2 - 10.1093/nass/49.1.367

DO - 10.1093/nass/49.1.367

M3 - Article

C2 - 17150786

AN - SCOPUS:34447101429

SN - 1746-8272

SP - 367

EP - 368

JO - Nucleic acids symposium series (2004)

JF - Nucleic acids symposium series (2004)

IS - 49

ER -

Inhibiting transcription of chromosomal DNA using antigene RNAs.

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this