TY - JOUR
T1 - Influence of vasoactive intestinal contractor on the feline pulmonary vascular bed
AU - Kadowitz, Philip J.
AU - Kvamme, Peter
AU - Nossaman, Bobby D.
AU - Ibrahim, Ikhlass N.
AU - Minkes, Robert K.
PY - 1991/2/26
Y1 - 1991/2/26
N2 - Pulmonary vascular responses to vasoactive intestinal contractor (VIC) (endothelin-B) were investigated in the feline pulmonary vascular bed under constant and natural flow conditions. Injection of VIC, 0.3 nmol/kg i.v., increased pulmonary arterial and left atrial pressures and cardiac output and caused a biphasic change in pulmonary vascular resistance. VIC and endothelin-1 (ET-1) caused a similar pattern of response and under constant flow conditions, VIC increased lobar arterial pressure in a dose-related manner and was similar in potency and duration of action to ET-1. The thromboxane mimic, U46619, was far more potent than VIC, and a monocyclic ET-analog had no activity in the pulmonary vascular bed. The present data show that VIC has significant vasoconstrictor activity in the pulmonary vascular bed of the cat.
AB - Pulmonary vascular responses to vasoactive intestinal contractor (VIC) (endothelin-B) were investigated in the feline pulmonary vascular bed under constant and natural flow conditions. Injection of VIC, 0.3 nmol/kg i.v., increased pulmonary arterial and left atrial pressures and cardiac output and caused a biphasic change in pulmonary vascular resistance. VIC and endothelin-1 (ET-1) caused a similar pattern of response and under constant flow conditions, VIC increased lobar arterial pressure in a dose-related manner and was similar in potency and duration of action to ET-1. The thromboxane mimic, U46619, was far more potent than VIC, and a monocyclic ET-analog had no activity in the pulmonary vascular bed. The present data show that VIC has significant vasoconstrictor activity in the pulmonary vascular bed of the cat.
KW - Endothelin-1
KW - Pulmonary vascular bed
KW - Vasoactive intestinal contractor
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U2 - 10.1016/0014-2999(91)90135-D
DO - 10.1016/0014-2999(91)90135-D
M3 - Article
C2 - 2060589
AN - SCOPUS:0026030780
SN - 0014-2999
VL - 194
SP - 127
EP - 130
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1
ER -