Influence of probe pressure on the diffuse correlation spectroscopy blood flow signal: Extra-cerebral contributions

Rickson C. Mesquita; Steven S. Schenkel; David L. Minkoff; Xiangping Lu; Christopher G. Favilla; Patrick M. Vora; David R. Busch; Malavika Chandra; Joel H. Greenberg; John A. Detre; A. G. Yodh

doi:10.1364/BOE.4.000978

Influence of probe pressure on the diffuse correlation spectroscopy blood flow signal: Extra-cerebral contributions

Rickson C. Mesquita, Steven S. Schenkel, David L. Minkoff, Xiangping Lu, Christopher G. Favilla, Patrick M. Vora, David R. Busch, Malavika Chandra, Joel H. Greenberg, John A. Detre, A. G. Yodh

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

A pilot study explores relative contributions of extra-cerebral (scalp/skull) versus brain (cerebral) tissues to the blood flow index determined by diffuse correlation spectroscopy (DCS). Microvascular DCS flow measurements were made on the head during baseline and breath-holding/hyperventilation tasks, both with and without pressure. Baseline (resting) data enabled estimation of extra-cerebral flow signals and their pressure dependencies. A simple two-component model was used to derive baseline and activated cerebral blood flow (CBF) signals, and the DCS flow indices were also cross-correlated with concurrent Transcranial Doppler Ultrasound (TCD) blood velocity measurements. The study suggests new pressure-dependent experimental paradigms for elucidation of blood flow contributions from extra-cerebral and cerebral tissues.

Original language	English (US)
Pages (from-to)	978-994
Number of pages	17
Journal	Biomedical Optics Express
Volume	4
Issue number	7
DOIs	https://doi.org/10.1364/BOE.4.000978
State	Published - 2013
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Atomic and Molecular Physics, and Optics

Access to Document

10.1364/BOE.4.000978

Cite this

@article{5424b8d305ce4c008a2cba354ebc671d,

title = "Influence of probe pressure on the diffuse correlation spectroscopy blood flow signal: Extra-cerebral contributions",

abstract = "A pilot study explores relative contributions of extra-cerebral (scalp/skull) versus brain (cerebral) tissues to the blood flow index determined by diffuse correlation spectroscopy (DCS). Microvascular DCS flow measurements were made on the head during baseline and breath-holding/hyperventilation tasks, both with and without pressure. Baseline (resting) data enabled estimation of extra-cerebral flow signals and their pressure dependencies. A simple two-component model was used to derive baseline and activated cerebral blood flow (CBF) signals, and the DCS flow indices were also cross-correlated with concurrent Transcranial Doppler Ultrasound (TCD) blood velocity measurements. The study suggests new pressure-dependent experimental paradigms for elucidation of blood flow contributions from extra-cerebral and cerebral tissues.",

author = "Mesquita, {Rickson C.} and Schenkel, {Steven S.} and Minkoff, {David L.} and Xiangping Lu and Favilla, {Christopher G.} and Vora, {Patrick M.} and Busch, {David R.} and Malavika Chandra and Greenberg, {Joel H.} and Detre, {John A.} and Yodh, {A. G.}",

year = "2013",

doi = "10.1364/BOE.4.000978",

language = "English (US)",

volume = "4",

pages = "978--994",

journal = "Biomedical Optics Express",

issn = "2156-7085",

publisher = "The Optical Society",

number = "7",

}

TY - JOUR

T1 - Influence of probe pressure on the diffuse correlation spectroscopy blood flow signal

T2 - Extra-cerebral contributions

AU - Mesquita, Rickson C.

AU - Schenkel, Steven S.

AU - Minkoff, David L.

AU - Lu, Xiangping

AU - Favilla, Christopher G.

AU - Vora, Patrick M.

AU - Busch, David R.

AU - Chandra, Malavika

AU - Greenberg, Joel H.

AU - Detre, John A.

AU - Yodh, A. G.

PY - 2013

Y1 - 2013

N2 - A pilot study explores relative contributions of extra-cerebral (scalp/skull) versus brain (cerebral) tissues to the blood flow index determined by diffuse correlation spectroscopy (DCS). Microvascular DCS flow measurements were made on the head during baseline and breath-holding/hyperventilation tasks, both with and without pressure. Baseline (resting) data enabled estimation of extra-cerebral flow signals and their pressure dependencies. A simple two-component model was used to derive baseline and activated cerebral blood flow (CBF) signals, and the DCS flow indices were also cross-correlated with concurrent Transcranial Doppler Ultrasound (TCD) blood velocity measurements. The study suggests new pressure-dependent experimental paradigms for elucidation of blood flow contributions from extra-cerebral and cerebral tissues.

AB - A pilot study explores relative contributions of extra-cerebral (scalp/skull) versus brain (cerebral) tissues to the blood flow index determined by diffuse correlation spectroscopy (DCS). Microvascular DCS flow measurements were made on the head during baseline and breath-holding/hyperventilation tasks, both with and without pressure. Baseline (resting) data enabled estimation of extra-cerebral flow signals and their pressure dependencies. A simple two-component model was used to derive baseline and activated cerebral blood flow (CBF) signals, and the DCS flow indices were also cross-correlated with concurrent Transcranial Doppler Ultrasound (TCD) blood velocity measurements. The study suggests new pressure-dependent experimental paradigms for elucidation of blood flow contributions from extra-cerebral and cerebral tissues.

UR - http://www.scopus.com/inward/record.url?scp=84879250121&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879250121&partnerID=8YFLogxK

U2 - 10.1364/BOE.4.000978

DO - 10.1364/BOE.4.000978

M3 - Article

C2 - 23847725

AN - SCOPUS:84879250121

SN - 2156-7085

VL - 4

SP - 978

EP - 994

JO - Biomedical Optics Express

JF - Biomedical Optics Express

IS - 7

ER -

Influence of probe pressure on the diffuse correlation spectroscopy blood flow signal: Extra-cerebral contributions

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this