Infantile mixed phenotype acute leukemia (bilineal and biphenotypic) with t(10;11)(p12;q23);MLL-MLLT10

Zhenjun Lou; Chengcheng Zhang; Carlos A. Tirado; Tamra L Slone; Junke Zheng; Charles M. Zaremba; Dwight H Oliver; Weina Chen

doi:10.1016/j.leukres.2010.02.029

Infantile mixed phenotype acute leukemia (bilineal and biphenotypic) with t(10;11)(p12;q23);MLL-MLLT10

Zhenjun Lou, Chengcheng Zhang, Carlos A. Tirado, Tamra L Slone, Junke Zheng, Charles M. Zaremba, Dwight H Oliver, Weina Chen

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

We report a case of a 6-month-old boy with a mixed phenotype acute leukemia (MPAL), bilineal and biphenotypic immunophenotype (B-lymphoid lineage and combined B-lymphoid and monocytic lineage) with t(10;11)(p12;q23);. MLL-MLLT10. He was treated with acute myeloid leukemia protocol and in complete remission at 7-month follow-up. To the best of our knowledge, this is the first reported MLL-MLLT10 rearranged case presenting as MPAL in an infant. From a clinical practice standpoint, this case illustrates the importance of detection of MLL rearrangement due to its prognostic implication and the effectiveness of flow cytometry immunophenotyping in diagnosing MPAL and monitoring minimal residual disease.

Original language	English (US)
Pages (from-to)	1107-1109
Number of pages	3
Journal	Leukemia Research
Volume	34
Issue number	8
DOIs	https://doi.org/10.1016/j.leukres.2010.02.029
State	Published - Aug 2010

Keywords

Flow cytometry
MLL-MLLT10
Mixed phenotype acute leukemia
T(10 ;11)(p12 ;q23)

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1016/j.leukres.2010.02.029

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title = "Infantile mixed phenotype acute leukemia (bilineal and biphenotypic) with t(10;11)(p12;q23);MLL-MLLT10",

abstract = "We report a case of a 6-month-old boy with a mixed phenotype acute leukemia (MPAL), bilineal and biphenotypic immunophenotype (B-lymphoid lineage and combined B-lymphoid and monocytic lineage) with t(10;11)(p12;q23);. MLL-MLLT10. He was treated with acute myeloid leukemia protocol and in complete remission at 7-month follow-up. To the best of our knowledge, this is the first reported MLL-MLLT10 rearranged case presenting as MPAL in an infant. From a clinical practice standpoint, this case illustrates the importance of detection of MLL rearrangement due to its prognostic implication and the effectiveness of flow cytometry immunophenotyping in diagnosing MPAL and monitoring minimal residual disease.",

keywords = "Flow cytometry, MLL-MLLT10, Mixed phenotype acute leukemia, T(10 ;11)(p12 ;q23)",

author = "Zhenjun Lou and Chengcheng Zhang and Tirado, {Carlos A.} and Slone, {Tamra L} and Junke Zheng and Zaremba, {Charles M.} and Oliver, {Dwight H} and Weina Chen",

year = "2010",

month = aug,

doi = "10.1016/j.leukres.2010.02.029",

language = "English (US)",

volume = "34",

pages = "1107--1109",

journal = "Leukemia Research",

issn = "0145-2126",

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T1 - Infantile mixed phenotype acute leukemia (bilineal and biphenotypic) with t(10;11)(p12;q23);MLL-MLLT10

AU - Lou, Zhenjun

AU - Zhang, Chengcheng

AU - Tirado, Carlos A.

AU - Slone, Tamra L

AU - Zheng, Junke

AU - Zaremba, Charles M.

AU - Oliver, Dwight H

AU - Chen, Weina

PY - 2010/8

Y1 - 2010/8

N2 - We report a case of a 6-month-old boy with a mixed phenotype acute leukemia (MPAL), bilineal and biphenotypic immunophenotype (B-lymphoid lineage and combined B-lymphoid and monocytic lineage) with t(10;11)(p12;q23);. MLL-MLLT10. He was treated with acute myeloid leukemia protocol and in complete remission at 7-month follow-up. To the best of our knowledge, this is the first reported MLL-MLLT10 rearranged case presenting as MPAL in an infant. From a clinical practice standpoint, this case illustrates the importance of detection of MLL rearrangement due to its prognostic implication and the effectiveness of flow cytometry immunophenotyping in diagnosing MPAL and monitoring minimal residual disease.

AB - We report a case of a 6-month-old boy with a mixed phenotype acute leukemia (MPAL), bilineal and biphenotypic immunophenotype (B-lymphoid lineage and combined B-lymphoid and monocytic lineage) with t(10;11)(p12;q23);. MLL-MLLT10. He was treated with acute myeloid leukemia protocol and in complete remission at 7-month follow-up. To the best of our knowledge, this is the first reported MLL-MLLT10 rearranged case presenting as MPAL in an infant. From a clinical practice standpoint, this case illustrates the importance of detection of MLL rearrangement due to its prognostic implication and the effectiveness of flow cytometry immunophenotyping in diagnosing MPAL and monitoring minimal residual disease.

KW - Flow cytometry

KW - MLL-MLLT10

KW - Mixed phenotype acute leukemia

KW - T(10 ;11)(p12 ;q23)

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DO - 10.1016/j.leukres.2010.02.029

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AN - SCOPUS:77953615293

SN - 0145-2126

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SP - 1107

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JO - Leukemia Research

JF - Leukemia Research

IS - 8

ER -

Infantile mixed phenotype acute leukemia (bilineal and biphenotypic) with t(10;11)(p12;q23);MLL-MLLT10

Abstract

Keywords

ASJC Scopus subject areas

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