TY - JOUR
T1 - Induction of NMDA receptor-dependent long-term depression in visual cortex does not require metabotropic glutamate receptors
AU - Sawtell, Nathaniel B.
AU - Huber, Kimberly M.
AU - Roder, John C.
AU - Bear, Mark F.
PY - 1999
Y1 - 1999
N2 - We tested the role of group I mGluRs in the induction of long-term depression (LTD) in the visual cortex, using the novel mGluR antagonist LY341495 and mice lacking mGluR5, the predominant phosphoinositide (PI)- linked mGluR in the visual cortex. We find that LY341495 is a potent blocker of glutamate-stimulated PI hydrolysis in visual cortical synaptoneurosomes, and that it effectively antagonizes the actions of the mGluR agonist 1S,3R- aminocyclopentane-1,3-dicarboxylic acid (ACPD) on synaptic transmission in visual cortical slices. However, LY341495 has no effect on the induction of LTD by low-frequency stimulation. Furthermore, mice lacking mGluR5 show normal NMDA receptor-dependent LTD. These results indicate that group I mGluR activation is not required for the induction of NMDA receptor-dependent LTD in the visual cortex.
AB - We tested the role of group I mGluRs in the induction of long-term depression (LTD) in the visual cortex, using the novel mGluR antagonist LY341495 and mice lacking mGluR5, the predominant phosphoinositide (PI)- linked mGluR in the visual cortex. We find that LY341495 is a potent blocker of glutamate-stimulated PI hydrolysis in visual cortical synaptoneurosomes, and that it effectively antagonizes the actions of the mGluR agonist 1S,3R- aminocyclopentane-1,3-dicarboxylic acid (ACPD) on synaptic transmission in visual cortical slices. However, LY341495 has no effect on the induction of LTD by low-frequency stimulation. Furthermore, mice lacking mGluR5 show normal NMDA receptor-dependent LTD. These results indicate that group I mGluR activation is not required for the induction of NMDA receptor-dependent LTD in the visual cortex.
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U2 - 10.1152/jn.1999.82.6.3594
DO - 10.1152/jn.1999.82.6.3594
M3 - Article
C2 - 10601487
AN - SCOPUS:0033394919
SN - 0022-3077
VL - 82
SP - 3594
EP - 3597
JO - Journal of neurophysiology
JF - Journal of neurophysiology
IS - 6
ER -