TY - JOUR
T1 - Induction of dendritic cell differentiation by IFN-α in systemic lupus erythematosus
AU - Blanco, P.
AU - Palucka, A. K.
AU - Gill, M.
AU - Pascual, V.
AU - Banchereau, J.
PY - 2001/11/16
Y1 - 2001/11/16
N2 - Dendritic cells (DCs) are important in regulating both immunity and tolerance. Hence, we hypothesized that systemic lupus erythematosus (SLE), an autoimmune disease characterized by autoreactive B and T cells, may be caused by alterations in the functions of DCs. Consistent with this, monocytes from SLE patients' blood were found to function as antigen-presenting cells, in vitro. Furthermore, serum from SLE patients induced normal monocytes to differentiate into DCs. These DCs could capture antigens from dying cells and present them to CD4-positive T cells. The capacity of SLE patients' serum to induce DC differentiation correlated with disease activity and depended on the actions of interferon-α (IFN-α). Thus, unabated induction of DCs by IFN-α may drive the autoimmune response in SLE.
AB - Dendritic cells (DCs) are important in regulating both immunity and tolerance. Hence, we hypothesized that systemic lupus erythematosus (SLE), an autoimmune disease characterized by autoreactive B and T cells, may be caused by alterations in the functions of DCs. Consistent with this, monocytes from SLE patients' blood were found to function as antigen-presenting cells, in vitro. Furthermore, serum from SLE patients induced normal monocytes to differentiate into DCs. These DCs could capture antigens from dying cells and present them to CD4-positive T cells. The capacity of SLE patients' serum to induce DC differentiation correlated with disease activity and depended on the actions of interferon-α (IFN-α). Thus, unabated induction of DCs by IFN-α may drive the autoimmune response in SLE.
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U2 - 10.1126/science.1064890
DO - 10.1126/science.1064890
M3 - Article
C2 - 11711679
AN - SCOPUS:0035900481
SN - 0036-8075
VL - 294
SP - 1540
EP - 1543
JO - Science
JF - Science
IS - 5546
ER -