Abstract
Studies have demonstrated neuronal expression of class I major histocompatibility complex (MHC) mRNA and protein in normal and developing brain and in response to injury or viral infection. We report neuronal expression of class I MHC mRNA in hypothalamic paraventricular nucleus (PVN) neurons in rats following systemic infection with Trypanosoma brucei brucei parasites (chronic) and in response to intravenous 1 mg/kg lipopolysaccharide administration (acute peripheral) and in striatal neurons following intrastriatal 5 μg lipopolysaccharide injection (acute central). These results demonstrate that neurons can be a source of immune signaling molecules and establish class I MHC as part of the neuronal component of immune responses.
Original language | English (US) |
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Pages (from-to) | 83-91 |
Number of pages | 9 |
Journal | Journal of Neuroimmunology |
Volume | 131 |
Issue number | 1-2 |
DOIs | |
State | Published - Oct 2002 |
Externally published | Yes |
Keywords
- In vivo
- Lipopolysaccharide
- Neuroimmune
- Sprague-Dawley
- Trypanosome
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology