Indole diterpenoid synthetic studies. The total synthesis of (+)-nodulisporic acid F

Amos B. Smith, Akin H. Davulcu, László Kürti

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


A stereocontrolled total synthesis of (+)-nodulisporic acid F, the simplest member of a family of novel ectoparasiticidal agents, has been achieved. Highlights of the effective modular synthetic strategy include anionic union of a tricyclic lactone with o-toluidine via our 2-substituted indole synthetic protocol, an optimized C-ring construction protocol, and a late-stage installation of the α,β-unsaturated carboxylic acid side chain via the B-alkyl Suzuki-Miyaura cross-coupling tactic.

Original languageEnglish (US)
Pages (from-to)1665-1668
Number of pages4
JournalOrganic Letters
Issue number8
StatePublished - Apr 13 2006

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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