Indole diterpenoid synthetic studies. Construction of the heptacyclic core of (-)-nodulisporic acid D

Amos B. Smith; Akin H. Davulcu; László Kürti

doi:10.1021/ol0602912

Indole diterpenoid synthetic studies. Construction of the heptacyclic core of (-)-nodulisporic acid D

Amos B. Smith, Akin H. Davulcu, László Kürti

Biochemistry

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Construction of the heptacyclic core of (-)-nodulisporic acid D, a representative member of a recently discovered class of architecturally complex, ectoparasiticidal indole alkaloids, has been achieved. The modular synthetic strategy comprises an expedient, stereocontrolled synthesis of a tricyclic western hemisphere, in conjunction with union of an eastern hemisphere, exploiting the 2-substituted indole synthetic protocol introduced and developed in our laboratory.

Original language	English (US)
Pages (from-to)	1669-1672
Number of pages	4
Journal	Organic Letters
Volume	8
Issue number	8
DOIs	https://doi.org/10.1021/ol0602912
State	Published - Apr 13 2006

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol0602912

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Indole diterpenoid synthetic studies. Construction of the heptacyclic core of (-)-nodulisporic acid D

Abstract

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