Abstract
(Chemical Equation Presented) A second-generation strategy for construction of (+)-nodulisporic acids A and B based on the development of a new, effective modular indole synthesis exploiting a sequential Stille cross-coupling/Buchwald- Hartwig union/cyclization tactic is disclosed. This strategy evolved due to the considerable acid instability of the C(24) hydroxyl group observed in several advanced intermediates during our first-generation approach.
Original language | English (US) |
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Pages (from-to) | 4611-4620 |
Number of pages | 10 |
Journal | Journal of Organic Chemistry |
Volume | 72 |
Issue number | 13 |
DOIs | |
State | Published - Jun 22 2007 |
ASJC Scopus subject areas
- Organic Chemistry