@article{9f74cb4f7141478cab5d9bd10a5955bf,
title = "Increased susceptibility to lethal lipopolysaccharide in mice with effects of bacterial b-cell leukemia",
abstract = "Susceptibility to the lethal effects of bacterial lipopolysaccharide (LPS) increased more than one hundredfold in BALB/c mice given syngeneic B-cell tumor transplants. The increased susceptibility to LPS that developed during the following weeks paralleled tumor growth in the liver and spleen. The tumor-bearing animals also developed an enhanced capacity to clear colloidal carbon from the blood, consistent with increased activity of the reticuloendothelial system. Although hypersusceptibility to LPS had been reported in a number of animal models, our experiment was the first demonstration in a tumor model that susceptibility correlates with tumor burden.",
author = "Muirhead, {M. J.} and Vitetta, {E. S.} and Isakson, {P. C.} and Krolick, {K. A.} and Dees, {J. H.} and Uhr, {J. W.}",
note = "Funding Information: , Received June 24, 1980; accepted September 26, 1980. 2 Supported by Public Health Service Grants AI1l851 and AIl2789 from the National Institute of Allergy and Infectious Diseases and by grant CA23115 from the National Cancer Institute. 3 Research procedures in this study were in accord with the ethical standards of the University of Texas Health Science Center at Dallas. 4 Department of Microbiology, Southwestern Medical School, University of Texas Health Science Center at Dallas, Dallas, Tex. 75235. 5 Department of Biochemistry, Southwestern Medical School, University of Texas Health Science Center at Dallas. 6 We thank Ms. S. Black, Ms. Y. M. Tseng, Ms. M. Bagby, and Mr. S. Chinn for excellent technical assistance. and Ms. D. Marcoulides and Ms. J. Hahn for secretarial assistance in the preparation of this manuscript.",
year = "1981",
month = apr,
doi = "10.1093/jnci/66.4.745",
language = "English (US)",
volume = "66",
pages = "745--753",
journal = "Journal of the National Cancer Institute",
issn = "0027-8874",
publisher = "Oxford University Press",
number = "4",
}