Increased norepinephrine synthesis in the cerebral hemispheres of rats following subarachnoid hemorrhage

Bruce M. McCormack; Dale M. Swift; Margarett T. Hegemann; Robert A. Solomon

doi:10.1016/0006-8993(86)91351-X

Increased norepinephrine synthesis in the cerebral hemispheres of rats following subarachnoid hemorrhage

Bruce M. McCormack, Dale M. Swift, Margarett T. Hegemann, Robert A. Solomon

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Norepinephrine (NE) was assayed in rat brains 72 h after the creation of an experimental subarachnoid hemorrhage (SAH). NE in the cerebral hemispheres was found to increase by 64% when compared to controls. NE in the brainstem and cerebellum was unchanged. The kinetics of hemispheric NE metabolism were then studied in control and SAH rats. SAH caused a 3-fold increase in NE synthesis and a 44% reduction in turnover time when compared to controls. These results may reflect increased activity of central noradrenergic neuronal pathways in SAH.

Original language	English (US)
Pages (from-to)	395-398
Number of pages	4
Journal	Brain Research
Volume	382
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(86)91351-X
State	Published - Sep 24 1986

Keywords

locus coeruleus
norpinephrine
subarachnoid hemorrhage

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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title = "Increased norepinephrine synthesis in the cerebral hemispheres of rats following subarachnoid hemorrhage",

abstract = "Norepinephrine (NE) was assayed in rat brains 72 h after the creation of an experimental subarachnoid hemorrhage (SAH). NE in the cerebral hemispheres was found to increase by 64% when compared to controls. NE in the brainstem and cerebellum was unchanged. The kinetics of hemispheric NE metabolism were then studied in control and SAH rats. SAH caused a 3-fold increase in NE synthesis and a 44% reduction in turnover time when compared to controls. These results may reflect increased activity of central noradrenergic neuronal pathways in SAH.",

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AU - McCormack, Bruce M.

AU - Swift, Dale M.

AU - Hegemann, Margarett T.

AU - Solomon, Robert A.

PY - 1986/9/24

Y1 - 1986/9/24

N2 - Norepinephrine (NE) was assayed in rat brains 72 h after the creation of an experimental subarachnoid hemorrhage (SAH). NE in the cerebral hemispheres was found to increase by 64% when compared to controls. NE in the brainstem and cerebellum was unchanged. The kinetics of hemispheric NE metabolism were then studied in control and SAH rats. SAH caused a 3-fold increase in NE synthesis and a 44% reduction in turnover time when compared to controls. These results may reflect increased activity of central noradrenergic neuronal pathways in SAH.

AB - Norepinephrine (NE) was assayed in rat brains 72 h after the creation of an experimental subarachnoid hemorrhage (SAH). NE in the cerebral hemispheres was found to increase by 64% when compared to controls. NE in the brainstem and cerebellum was unchanged. The kinetics of hemispheric NE metabolism were then studied in control and SAH rats. SAH caused a 3-fold increase in NE synthesis and a 44% reduction in turnover time when compared to controls. These results may reflect increased activity of central noradrenergic neuronal pathways in SAH.

KW - locus coeruleus

KW - norpinephrine

KW - subarachnoid hemorrhage

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Increased norepinephrine synthesis in the cerebral hemispheres of rats following subarachnoid hemorrhage

Abstract

Keywords

ASJC Scopus subject areas

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