Abstract
To assess potential roles of hepatocyte growth factor-like (HGFL) protein as a growth factor and as a cytokine, we determined the expression of mRNA for (HGFL) protein during liver regeneration and inflammation. Expression of mRNA for HGFL protein in the regenerating liver was upregulated to 93% and 64% above controls at 1 h following partial hepatectomy and carbon tetrachloride treatment of rats, respectively. Similarly, rat liver mRNA for HGFL protein was upregulated to 78% above controls at 24 h after injection of thioglycollate (inducing activation of peritoneal macrophages) and to 118% at 48 h after injection or turpentine (inducing the acute phase response). These results support a potential role for HGFL protein in the early phase of liver regeneration and as an inflammatory mediator.
Original language | English (US) |
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Pages (from-to) | 666-673 |
Number of pages | 8 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 203 |
Issue number | 1 |
DOIs | |
State | Published - Aug 30 1994 |
Externally published | Yes |
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology