Incidence of death and MI associated with stopping clopidogrel after ACS

P. Michael Ho, Eric D. Peterson, Li Wang, David J. Magid, Stephan D. Fihn, Greg C. Larsen, Robert A. Jesse, John S. Rumsfeld

Research output: Contribution to journalArticlepeer-review


Rates of death and myocardial infarction were assessed for a national sample of acute coronary syndrome patients after stopping clopidogrel, in the first 90 days after stopping treatment, patients experienced a nearly twofold increased risk of adverse events compared with subsequent follow-up intervals for patients treated medically without stents and for patients treated with coronary stents. This suggests a possible clopidogrel rebound effect, but additional studies are needed to support this hypothesis and to identify strategies to reduce early events after clopidogrel cessation.

Original languageEnglish (US)
Pages (from-to)13-18
Number of pages6
JournalCardiology Review
Issue number10
StatePublished - Oct 2008
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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