Inactivation of the Rps4 gene on the mouse X chromosome

Andrew R. Zinn, Steven L. Bressler, Peggy Beer-Romero, David A. Adler, Verne M. Chapman, David C. Page, Christine M. Disteche

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


The human RPS4X and RPS4Y genes, located on the X and Y chromosomes, appear to encode isoforms of ribosomal protein S4. Haploinsufficiency of these genes may contribute to the human phenotype known as Turner syndrome. Although RPS4X maps near the X-inactivation center, the gene is expressed on inactive human X chromosomes. We cloned Rps4, the mouse homolog of RPS4X. Exploiting allelic variation in Rps4, we examined transcription of the gene from active and inactive mouse X chromosomes in vivo, in female mice carrying an X-autosome translocation. We report that mouse Rps4, unlike human RPS4X, is subject to X inactivation. This finding may explain, at least in part, why the phenotypic consequences of X monosomy are less severe in mice than in humans.

Original languageEnglish (US)
Pages (from-to)1097-1101
Number of pages5
Issue number4
StatePublished - Dec 1991

ASJC Scopus subject areas

  • Genetics


Dive into the research topics of 'Inactivation of the Rps4 gene on the mouse X chromosome'. Together they form a unique fingerprint.

Cite this