In vivo stereological assessment of caudate volume in man: Effect of normal aging

K. Ranga Krishnan; M. M. Husain; W. M. McDonald; P. M. Doraiswamy; G. S. Figiel; O. B. Boyko; E. H. Ellinwood; C. B. Nemeroff

doi:10.1016/0024-3205(90)90196-X

In vivo stereological assessment of caudate volume in man: Effect of normal aging

K. Ranga Krishnan, M. M. Husain, W. M. McDonald, P. M. Doraiswamy, G. S. Figiel, O. B. Boyko, E. H. Ellinwood, C. B. Nemeroff

Research output: Contribution to journal › Article › peer-review

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Abstract

Using intermediate weighted magnetic resonance imaging (MRI) and a systematic sampling stereological method in 39 normal volunteers aged 24-79 years old, we demonstrated a marked age-associated decline in caudate nuclei volume (r = -0.69, p < 0.0001). The mean absolute volume of the caudate nuclei in this study (9.4 cm³) was almost identical to that reported in a previous autopsy study and further confirms the validity of this stereological technique for use with MR images. This technique will provide a method for measuring the caudate and other nuclei in vivo, from brain images and, as such, a research tool to correlate age-associated changes in cognitive, sensory and motor function with caudate nucleus volume and other brain regions.

Original language	English (US)
Pages (from-to)	1325-1329
Number of pages	5
Journal	Life Sciences
Volume	47
Issue number	15
DOIs	https://doi.org/10.1016/0024-3205(90)90196-X
State	Published - 1990

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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@article{8ce06610d6844c51bfa4452d9e9071be,

title = "In vivo stereological assessment of caudate volume in man: Effect of normal aging",

abstract = "Using intermediate weighted magnetic resonance imaging (MRI) and a systematic sampling stereological method in 39 normal volunteers aged 24-79 years old, we demonstrated a marked age-associated decline in caudate nuclei volume (r = -0.69, p < 0.0001). The mean absolute volume of the caudate nuclei in this study (9.4 cm3) was almost identical to that reported in a previous autopsy study and further confirms the validity of this stereological technique for use with MR images. This technique will provide a method for measuring the caudate and other nuclei in vivo, from brain images and, as such, a research tool to correlate age-associated changes in cognitive, sensory and motor function with caudate nucleus volume and other brain regions.",

author = "{Ranga Krishnan}, K. and Husain, {M. M.} and McDonald, {W. M.} and Doraiswamy, {P. M.} and Figiel, {G. S.} and Boyko, {O. B.} and Ellinwood, {E. H.} and Nemeroff, {C. B.}",

note = "Funding Information: Supported by NIMH MH-40139, MH-40159, MH-44716, and MH-42088.",

year = "1990",

doi = "10.1016/0024-3205(90)90196-X",

language = "English (US)",

volume = "47",

pages = "1325--1329",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "15",

}

TY - JOUR

T1 - In vivo stereological assessment of caudate volume in man

T2 - Effect of normal aging

AU - Ranga Krishnan, K.

AU - Husain, M. M.

AU - McDonald, W. M.

AU - Doraiswamy, P. M.

AU - Figiel, G. S.

AU - Boyko, O. B.

AU - Ellinwood, E. H.

AU - Nemeroff, C. B.

N1 - Funding Information: Supported by NIMH MH-40139, MH-40159, MH-44716, and MH-42088.

PY - 1990

Y1 - 1990

N2 - Using intermediate weighted magnetic resonance imaging (MRI) and a systematic sampling stereological method in 39 normal volunteers aged 24-79 years old, we demonstrated a marked age-associated decline in caudate nuclei volume (r = -0.69, p < 0.0001). The mean absolute volume of the caudate nuclei in this study (9.4 cm3) was almost identical to that reported in a previous autopsy study and further confirms the validity of this stereological technique for use with MR images. This technique will provide a method for measuring the caudate and other nuclei in vivo, from brain images and, as such, a research tool to correlate age-associated changes in cognitive, sensory and motor function with caudate nucleus volume and other brain regions.

AB - Using intermediate weighted magnetic resonance imaging (MRI) and a systematic sampling stereological method in 39 normal volunteers aged 24-79 years old, we demonstrated a marked age-associated decline in caudate nuclei volume (r = -0.69, p < 0.0001). The mean absolute volume of the caudate nuclei in this study (9.4 cm3) was almost identical to that reported in a previous autopsy study and further confirms the validity of this stereological technique for use with MR images. This technique will provide a method for measuring the caudate and other nuclei in vivo, from brain images and, as such, a research tool to correlate age-associated changes in cognitive, sensory and motor function with caudate nucleus volume and other brain regions.

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DO - 10.1016/0024-3205(90)90196-X

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SP - 1325

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JO - Life Sciences

JF - Life Sciences

IS - 15

ER -

In vivo stereological assessment of caudate volume in man: Effect of normal aging

Abstract

ASJC Scopus subject areas

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