In vivo proton spectroscopy without solvent suppression

David B. Clayton, Mark A. Elliott, Robert E. Lenkinski

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


In 1H MR spectroscopy of the human brain, it is common practice to suppress the solvent signal prior to acquisition. This reduces the large dynamic range which is otherwise required of the MR receiver and digitizer in order to detect the dilute metabolite resonances in the presence of the much larger water signal. However, complete solvent suppression is not always obtainable, particularly over large volumes and in superficial regions containing large susceptibility gradients. In this work, it demonstrated that modern commercial MR scanners possess the dynamic range necessary to adequately resolve the 1H metabolites in unsuppressed spectra. Moreover, a postacquisition method is presented which can completely remove the intact water signal and accurately quantitate the metabolite peaks. Preserving the water signal in in vivo spectroscopy has several useful benefits, such as providing a high signal-to-noise ratio internal concentration, frequency, and line shape reference. Comparison is made between suppressed and unsuppressed spectra from both a phantom and the human brain acquired at 4 T.

Original languageEnglish (US)
Pages (from-to)260-275
Number of pages16
JournalConcepts in Magnetic Resonance
Issue number4
StatePublished - Jan 1 2001


  • Dynamic range
  • HSVD
  • Quantization
  • Unsuppressed

ASJC Scopus subject areas

  • Chemistry(all)
  • Spectroscopy
  • Physical and Theoretical Chemistry


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