In vivo and in vitro diagnosis of drug allergy

R. S. Gruchalla, T. J. Sullivan

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


A significant number of adverse drug reactions resemble immunopathologic reactions. The development of in vivo and in vitro assays for drug-specific antibodies and lymphocytes has provided critical information regarding the underlying mechanisms of these reactions. These assays provide evidence that indeed some adverse drug reactions have an immunologic basis, and they make it possible to now study the relationships between specific arrays of immune responses to drugs and clinical phenomena.

Original languageEnglish (US)
Pages (from-to)595-610
Number of pages16
JournalImmunology and Allergy Clinics of North America
Issue number3
StatePublished - 1991

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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