In Vitro Susceptibility of Shigellae to Sodium Sulfadiazine and to Eight Antibiotics

Kenneth C. Haltalin, John D. Nelson

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


More than 300 recently isolated Shigella strains were tested for susceptibility, to sodium sulfadiazine by tube and plate dilution techniques. With a low inoculum (100 organisms), 59% of Shigella flexneri and 87% of S sonnei were sulfadiazine resistant. All strains were resistant by high inoculum testing (2 × 106 organisms). Antibiotic susceptibility testing by the plate dilution method using high inocula demonstrated by the following percentages of resistance: potassium penicillin G, 93%; streptomycin, 17%; tetracycline hydrochloride, 12%; chloramphenicol, 11%; ampicillin, 6%; sodium colistimethate, 2%; kanamycin sulfate, 1%; and neomycin sulfate, 1%. These studies indicate that sulfadiazine is no longer an appropriate drug for initiating treatment of shigellosis. Ampicillin and three orally administered non-absorbable antibiotics (colistimethate, kanamycin and neomycin) are the most effective drugs against shigellae in vitro.

Original languageEnglish (US)
Pages (from-to)705-710
Number of pages6
JournalJAMA: The Journal of the American Medical Association
Issue number9
StatePublished - Aug 30 1965

ASJC Scopus subject areas

  • Medicine(all)


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