TY - JOUR
T1 - In Vitro Study of Cytotoxic Factors Against Endothelium in Childhood Dermatomyositis
AU - Iannaccone, S. T.
AU - Bowen, D.
AU - Yarom, A.
AU - Ciraolo, G.
PY - 1984/8
Y1 - 1984/8
N2 - In a previous report we showed that leukocytes from a group of patients with childhood dermatomyositis (CDM) were not cytotoxic toward cultured normal human skeletal muscle cells. Blood products from 11 patients with CDM and 12 age- and sex-matched controls were tested for cytotoxicity toward human endothelium using a chromium 51 assay. Mixed lymphocytes, monocytes, and serum alone or in combination did not produce endothelial cell death. The combination of serum and leukocytes, however, did produce some cytotoxic effects in three of 11 patients with CDM. We conclude that those factors tested in vitro are not responsible for the endothelial cell death but together may produce cytotoxic changes in some patients.
AB - In a previous report we showed that leukocytes from a group of patients with childhood dermatomyositis (CDM) were not cytotoxic toward cultured normal human skeletal muscle cells. Blood products from 11 patients with CDM and 12 age- and sex-matched controls were tested for cytotoxicity toward human endothelium using a chromium 51 assay. Mixed lymphocytes, monocytes, and serum alone or in combination did not produce endothelial cell death. The combination of serum and leukocytes, however, did produce some cytotoxic effects in three of 11 patients with CDM. We conclude that those factors tested in vitro are not responsible for the endothelial cell death but together may produce cytotoxic changes in some patients.
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U2 - 10.1001/archneur.1984.04050190068016
DO - 10.1001/archneur.1984.04050190068016
M3 - Article
C2 - 6466161
AN - SCOPUS:0021266279
SN - 0003-9942
VL - 41
SP - 862
EP - 864
JO - Archives of neurology
JF - Archives of neurology
IS - 8
ER -