In Vitro MR Imaging of Renal Stones with an Ultra-short Echo Time Magnetic Resonance Imaging Sequence

Aya Yassin, Ivan Pedrosa, Michael Kearney, Elizabeth Genega, Neil M. Rofsky, Robert E. Lenkinski

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Objectives: To characterize the magnetic resonance (MR) relaxation times (ie, T1 and T2 relaxation times) of a variety of kidney stone specimens using an ultra-short echo time (UTE) sequence and to correlate these values to their size and composition based on chemical analysis. Materials and Methods: This was an institutional review board-approved, Health Insurance Portability and Accountability Act-compliant study with waiver of informed consent. Between April 2009 and September 2009, stones from 36 patients underwent 1.5T MR imaging with two UTE pulse sequences to measure: 1) T2 relaxation times (repetition time [TR] = 1 second and multiple echo times [TEs] ranging from 0.1 ms up to 2 ms); 2) T1 relaxation times (TE = 0.1 ms and multiple TRs ranging from 500 ms to 2.5 seconds). A tube containing a solution of water and hydroxyapatite crystals near the stones served as reference standard. Results were compared to previous data obtained from experiments measuring the T1 and T2 of pure calcium oxalate and hydroxyapatite crystals suspended in water. Stones were submitted for chemical analysis. The stone size and composition was correlated to the relaxation time, and signal intensity. Results: The average stone size was 0.86 cm (range 0.1-3.3 cm). Twenty-one stones were visible by MR. The average size of MR-visible stones was 1.1 cm (range 0.15-3.3 cm) compared to 0.46 cm (range 0.1-0.9) for nonvisible stones. The mean T1 and T2 of MR-visible stones were 950 ms (range 138-3000 ms) and 3.12 ms (range 0.27-12 ms), respectively. The T1 (mean 1143, range 740-1583) and T1 (mean 8.31, range 4.6-12) values of calcium phosphate were longer than that for other stone compositions T1 (mean 953, range 138-3000) and T2 (mean 2.58, range 0.27-5.8; P < 05). Conclusions: The T1- and T2-relaxation times of kidney stones are variable and depend on their composition and the size of the stones. UTE MR allows for visualization of renal stones in vitro.

Original languageEnglish (US)
Pages (from-to)1566-1572
Number of pages7
JournalAcademic radiology
Issue number12
StatePublished - Dec 2012


  • Kidney stones
  • Renal stones
  • Urinary calculi

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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