In vitro cartilage explant injury models

Christopher T. Chen, Peter A. Torzilli

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations


Mechanical injury resulting from a single impact or repetitive overloads is the major factor for the onset of post-traumatic arthritis. Researchers have used a variety of explant injury models to study the role of biomechanical factors in cartilage injury in vitro. Although these models cannot emulate all of the events occurring in an injured joint, they allow the evaluation of acute cellular responses and specific degradation mechanisms in well-defined explant culture environment using reproducible loading regimens. This chapter reviews the studies that utilize various loading systems to investigate cartilage injury, and to compare the results in terms of cell death and matrix damage in cartilage. In doing so, the reader will obtain a better understanding of the major biomechanical factors in cartilage injury and how they contribute to post-traumatic arthritis.

Original languageEnglish (US)
Title of host publicationPost-Traumatic Arthritis
Subtitle of host publicationPathogenesis, Diagnosis and Management
PublisherSpringer US
Number of pages12
ISBN (Electronic)9781489976062
ISBN (Print)9781489976055
StatePublished - Jan 1 2015


  • Articular cartilage
  • Cell death
  • Displacement-control
  • Drop tower
  • Load-control
  • Matrix degradation
  • Post-traumatic arthritis
  • Repetitive overloads
  • Traumatic impact

ASJC Scopus subject areas

  • General Medicine


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