@article{b1d67fdff58f4ff69623214e400629ee,
title = "In vitro and in vivo studies of a chlorin-based carbon nanocarrier with photodynamic therapy features",
abstract = "Carbonaceous materials have long been developed to utilize “nano-spaces” and numerous guest species could be encapsulated. A remarkable fluorescence difference has been observed after newly designed pyropheophorbide-a-appended carbon nanohorns were incorporated in a cellular medium and confocal microscopy was employed for the determination of the intracellular localization. Our study supported the role of carbon nanohorns as carriers of photodynamic therapy (PDT) agents and their heating behavior was discussed. We have developed a theranostic platform based on photosensitizer-conjugated carbon nanostructures and this system has been applied in an animal model. In addition, a negligible toxicity of CNH-Pyro was found in body weight experiments and histopathological examination of the major organs.",
author = "Zhan Zhou and Yuhui Zheng and Zhang, {Cheng Cheng} and Jinwei Gao and Yiping Tang and Qianming Wang",
note = "Funding Information: Q. M. acknowledges the support from the Special Project of Applicable Science and Technology of Guangdong Province (No. 2016B020240008) and the Guangdong Science and Technology plan (2016A050502053). Support to C. C. Z. was from the NIH grant 1R01CA172268, the Leukemia & Lymphoma Society Award 1024-14 and the CPRIT RP140402. Z. Z. acknowledges the National Natural Science Foundation of Henan (162300410200), the Scientific Research Fund of Henan Provincial Education Department (No. 17A150016) and the China Scholarship Council (CSC) for financial support. J. W. acknowledges the support from the National Natural Science Foundation of China (51571094), and the Innovation team project by the Department of Education of Guangdong Province (2016KCXTD009). Publisher Copyright: {\textcopyright} The Royal Society of Chemistry and Owner Societies.",
year = "2018",
doi = "10.1039/C8PP00287H",
language = "English (US)",
volume = "17",
pages = "1329--1336",
journal = "Photochemical and Photobiological Sciences",
issn = "1474-905X",
publisher = "Royal Society of Chemistry",
number = "10",
}