TY - JOUR
T1 - In and out
T2 - Histone variant exchange in chromatin
AU - Jin, Jingji
AU - Cai, Yong
AU - Li, Bing
AU - Conaway, Ronald C.
AU - Workman, Jerry L.
AU - Conaway, Joan Weliky
AU - Kusch, Thomas
N1 - Funding Information:
We apologize to colleagues whose original work was not cited owing to space limitations. This work was supported in part by NIH grants R37 GM41628 (to R.C.C.) and R37 GM47867 (to J.L.W.).
PY - 2005/12
Y1 - 2005/12
N2 - Alterations in nucleosome structure affect the accessibility of the DNA and can generate specialized domains of chromatin in the genome. Such changes can be introduced by posttranslational modifications of histones, by chromatin remodeling, or by the incorporation of variants of H2A and H3 into nucleosomes. In contrast to the canonical histones, which are deposited behind the replication fork during S phase, histone variants are incorporated in a process that is independent of DNA replication. Recent studies have shown that distinct multiprotein complexes are responsible for the targeted deposition of histone variants at active genes, centromeres and silent loci. The incorporation of histone variants most probably has epigenetic consequences and contributes to architectural changes in chromosomes.
AB - Alterations in nucleosome structure affect the accessibility of the DNA and can generate specialized domains of chromatin in the genome. Such changes can be introduced by posttranslational modifications of histones, by chromatin remodeling, or by the incorporation of variants of H2A and H3 into nucleosomes. In contrast to the canonical histones, which are deposited behind the replication fork during S phase, histone variants are incorporated in a process that is independent of DNA replication. Recent studies have shown that distinct multiprotein complexes are responsible for the targeted deposition of histone variants at active genes, centromeres and silent loci. The incorporation of histone variants most probably has epigenetic consequences and contributes to architectural changes in chromosomes.
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U2 - 10.1016/j.tibs.2005.10.003
DO - 10.1016/j.tibs.2005.10.003
M3 - Review article
C2 - 16257529
AN - SCOPUS:27944442030
SN - 0968-0004
VL - 30
SP - 680
EP - 687
JO - Trends in biochemical sciences
JF - Trends in biochemical sciences
IS - 12
ER -