Improving chemoradiotherapy with nanoparticle therapeutics

Michael Joseph Eblan; Andrew Zhuang Wang

doi:10.3978/j.issn.2218-676X.2013.08.04

Improving chemoradiotherapy with nanoparticle therapeutics

Michael Joseph Eblan, Andrew Zhuang Wang

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Chemoradiotherapy has been a key treatment paradigm in cancer management. One of the main research objectives in cancer research has been to identify agents and strategies to improve the therapeutic index of chemoradiation. Recent development of nanoparticle (NP)-based chemotherapeutics offers a unique opportunity to improve the delivery of chemotherapy, which can in turn improve chemoradiotherapy's efficacy while lowering toxicity. NP-based chemotherapeutics also possess several characteristics that are well suited for chemoradiotherapy. Therefore, NP chemotherapeutics hold high potential in improving the therapeutic index of chemoradiotherapy. This manuscript reviews the NP properties that are favorable for chemoradiation and the rationale to utilize nanotherapeutics in chemoradiation. This review also discusses the preclinical and clinical data on using NP therapeutics in chemoradiotherapy.

Original language	English (US)
Pages (from-to)	320-329
Number of pages	10
Journal	Translational Cancer Research
Volume	2
Issue number	4
DOIs	https://doi.org/10.3978/j.issn.2218-676X.2013.08.04
State	Published - Aug 1 2013
Externally published	Yes

Keywords

Chemoradiation
Nanomedicine
Nanoparticle (NP) chemotherapeutics
NP radiosensitizer

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

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10.3978/j.issn.2218-676X.2013.08.04

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title = "Improving chemoradiotherapy with nanoparticle therapeutics",

abstract = "Chemoradiotherapy has been a key treatment paradigm in cancer management. One of the main research objectives in cancer research has been to identify agents and strategies to improve the therapeutic index of chemoradiation. Recent development of nanoparticle (NP)-based chemotherapeutics offers a unique opportunity to improve the delivery of chemotherapy, which can in turn improve chemoradiotherapy's efficacy while lowering toxicity. NP-based chemotherapeutics also possess several characteristics that are well suited for chemoradiotherapy. Therefore, NP chemotherapeutics hold high potential in improving the therapeutic index of chemoradiotherapy. This manuscript reviews the NP properties that are favorable for chemoradiation and the rationale to utilize nanotherapeutics in chemoradiation. This review also discusses the preclinical and clinical data on using NP therapeutics in chemoradiotherapy.",

keywords = "Chemoradiation, Nanomedicine, Nanoparticle (NP) chemotherapeutics, NP radiosensitizer",

author = "Eblan, {Michael Joseph} and Wang, {Andrew Zhuang}",

note = "Funding Information: This work is supported by grants from the University Cancer Research Fund from the University of North Carolina. AZW is also supported by the National Institutes of Health Center for Nanotechnology Excellence Grant U54-CA151652 and National Cancer Institute R01 CA178748. Disclosure: The authors declare no conflict of interest. Publisher Copyright: {\textcopyright} 2011-2016 Translational Cancer Research.",

year = "2013",

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doi = "10.3978/j.issn.2218-676X.2013.08.04",

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AU - Eblan, Michael Joseph

AU - Wang, Andrew Zhuang

N1 - Funding Information: This work is supported by grants from the University Cancer Research Fund from the University of North Carolina. AZW is also supported by the National Institutes of Health Center for Nanotechnology Excellence Grant U54-CA151652 and National Cancer Institute R01 CA178748. Disclosure: The authors declare no conflict of interest. Publisher Copyright: © 2011-2016 Translational Cancer Research.

PY - 2013/8/1

Y1 - 2013/8/1

N2 - Chemoradiotherapy has been a key treatment paradigm in cancer management. One of the main research objectives in cancer research has been to identify agents and strategies to improve the therapeutic index of chemoradiation. Recent development of nanoparticle (NP)-based chemotherapeutics offers a unique opportunity to improve the delivery of chemotherapy, which can in turn improve chemoradiotherapy's efficacy while lowering toxicity. NP-based chemotherapeutics also possess several characteristics that are well suited for chemoradiotherapy. Therefore, NP chemotherapeutics hold high potential in improving the therapeutic index of chemoradiotherapy. This manuscript reviews the NP properties that are favorable for chemoradiation and the rationale to utilize nanotherapeutics in chemoradiation. This review also discusses the preclinical and clinical data on using NP therapeutics in chemoradiotherapy.

AB - Chemoradiotherapy has been a key treatment paradigm in cancer management. One of the main research objectives in cancer research has been to identify agents and strategies to improve the therapeutic index of chemoradiation. Recent development of nanoparticle (NP)-based chemotherapeutics offers a unique opportunity to improve the delivery of chemotherapy, which can in turn improve chemoradiotherapy's efficacy while lowering toxicity. NP-based chemotherapeutics also possess several characteristics that are well suited for chemoradiotherapy. Therefore, NP chemotherapeutics hold high potential in improving the therapeutic index of chemoradiotherapy. This manuscript reviews the NP properties that are favorable for chemoradiation and the rationale to utilize nanotherapeutics in chemoradiation. This review also discusses the preclinical and clinical data on using NP therapeutics in chemoradiotherapy.

KW - Chemoradiation

KW - Nanomedicine

KW - Nanoparticle (NP) chemotherapeutics

KW - NP radiosensitizer

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Improving chemoradiotherapy with nanoparticle therapeutics

Abstract

Keywords

ASJC Scopus subject areas

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