Improvement in Tardive Dyskinesia After Muscimol Therapy

C. A. Tamminga; J. W. Crayton; T. N. Chase

doi:10.1001/archpsyc.1979.01780050105013

Improvement in Tardive Dyskinesia After Muscimol Therapy

C. A. Tamminga, J. W. Crayton, T. N. Chase

Research output: Contribution to journal › Article › peer-review

99 Scopus citations

Abstract

Muscimol, thought to be a agonist of γ-aminobutyric acid (GABA), was administered to eight neuroleptic-free subjects with tardive dyskinesia. At oral dose levels from 5 to 9 mg, involuntary movements were consistently attenuated, usually in the absence of sedation. These results support the view that pharmacologic attempts to stimulate GABA-mediated synaptic transmission may afford symptomatic relief to patients with tardive dyskinesia.

Original language	English (US)
Pages (from-to)	595-598
Number of pages	4
Journal	Archives of General Psychiatry
Volume	36
Issue number	5
DOIs	https://doi.org/10.1001/archpsyc.1979.01780050105013
State	Published - May 1979

ASJC Scopus subject areas

Arts and Humanities (miscellaneous)
Psychiatry and Mental health

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abstract = "Muscimol, thought to be a agonist of γ-aminobutyric acid (GABA), was administered to eight neuroleptic-free subjects with tardive dyskinesia. At oral dose levels from 5 to 9 mg, involuntary movements were consistently attenuated, usually in the absence of sedation. These results support the view that pharmacologic attempts to stimulate GABA-mediated synaptic transmission may afford symptomatic relief to patients with tardive dyskinesia.",

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AU - Chase, T. N.

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AB - Muscimol, thought to be a agonist of γ-aminobutyric acid (GABA), was administered to eight neuroleptic-free subjects with tardive dyskinesia. At oral dose levels from 5 to 9 mg, involuntary movements were consistently attenuated, usually in the absence of sedation. These results support the view that pharmacologic attempts to stimulate GABA-mediated synaptic transmission may afford symptomatic relief to patients with tardive dyskinesia.

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Improvement in Tardive Dyskinesia After Muscimol Therapy

Abstract

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