Improved Diagnostic Sensitivity of Bowel Disease of Prematurity on Contrast-Enhanced Ultrasound

Jamaal L. Benjamin, Rebecca Dennis, Stacy White, David Munson, Sudha A. Anupindi, Maciej Piskunowicz, Kassa Darge, Ami Gokli, Misun Hwang

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Bowel diseases of prematurity, including necrotizing enterocolitis, are dreaded ailments of neonates. Early diagnosis is difficult, with clinical and radiographic findings often inconclusive. We present a novel use of contrast-enhanced ultrasound in detection of pediatric bowel disease. Early identification of compromised blood flow or an at-risk bowel can be quantitatively detected and monitored. This ability has implications for guidance of emerging therapies, allowing targeting of inflammation. These findings represent an advancement in detection of bowel disease in neonates.

Original languageEnglish (US)
Pages (from-to)1031-1036
Number of pages6
JournalJournal of Ultrasound in Medicine
Issue number5
StatePublished - May 1 2020
Externally publishedYes


  • bowel disease of prematurity
  • contrast-enhanced ultrasound
  • necrotizing enterocolitis
  • neonate

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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