TY - GEN
T1 - Improved biomarker performance for the detection of hepatocellular carcinoma by inclusion of clinical parameters
AU - Wang, Mengjun
AU - Block, Timothy M.
AU - Marrero, Jorge
AU - Di Bisceglie, Adrian M.
AU - Devarajan, Karthik
AU - Mehta, Anand
PY - 2012
Y1 - 2012
N2 - We have previously identified several biomarkers of hepatocellular carcinoma (HCC). The levels of three of these biomarkers were analyzed individually and in combination with the currently used marker, alpha fetoprotein (AFP), for the ability to distinguish between a diagnosis of cirrhosis (n=113) and HCC (n=164). We have utilized several novel biostatistical tools, along with the inclusion of clinical factors such as age and gender, to determine if improved algorithms could be used to increase the probability of detection of cancer. Using several of these methods, we are able to detect HCC in the background of cirrhosis with an AUC of at least 0.95. The use of clinical factors in combination with biomarker values to detect HCC is discussed.
AB - We have previously identified several biomarkers of hepatocellular carcinoma (HCC). The levels of three of these biomarkers were analyzed individually and in combination with the currently used marker, alpha fetoprotein (AFP), for the ability to distinguish between a diagnosis of cirrhosis (n=113) and HCC (n=164). We have utilized several novel biostatistical tools, along with the inclusion of clinical factors such as age and gender, to determine if improved algorithms could be used to increase the probability of detection of cancer. Using several of these methods, we are able to detect HCC in the background of cirrhosis with an AUC of at least 0.95. The use of clinical factors in combination with biomarker values to detect HCC is discussed.
KW - Hepatitis B virus
KW - Hepatocellular Carcinoma
KW - biomarkers
KW - classification and regression trees
KW - logistic regression
KW - penalized logistic regression
UR - http://www.scopus.com/inward/record.url?scp=84872504787&partnerID=8YFLogxK
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U2 - 10.1109/BIBM.2012.6392612
DO - 10.1109/BIBM.2012.6392612
M3 - Conference contribution
C2 - 24307972
AN - SCOPUS:84872504787
SN - 9781467325585
T3 - Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2012
SP - 534
EP - 538
BT - Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2012
T2 - 2012 IEEE International Conference on Bioinformatics and Biomedicine, BIBM2012
Y2 - 4 October 2012 through 7 October 2012
ER -