Abstract
The human apolipoprotein E isoforms, apoE2, apoE3, and apoE4, have differential effects on brain function. Compared to apoE3, apoE4 increases the risk of age-related cognitive decline in humans and female mice expressing apoE in neurons. Here, we show impaired spatial memory retention in female mice expressing apoE4 in astrocytes compared to those expressing apoE3 in astrocytes or lacking apoE. Thus, apoE4 impairs cognition whether expressed in neurons or astrocytes.
Original language | English (US) |
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Pages (from-to) | 372-375 |
Number of pages | 4 |
Journal | Behavioural Brain Research |
Volume | 176 |
Issue number | 2 |
DOIs | |
State | Published - Jan 25 2007 |
Keywords
- Apolipoprotein E
- Passive avoidance
- Rotorod
- Transgenic mice
- Water maze
ASJC Scopus subject areas
- Behavioral Neuroscience