Impaired response inhibition in ill Gulf War veterans

Gail D. Tillman; Timothy A. Green; Thomas C. Ferree; Clifford S. Calley; Mandy J. Maguire; Richard Briggs; John Hart; Robert W. Haley; Michael A. Kraut

doi:10.1016/j.jns.2010.07.021

Impaired response inhibition in ill Gulf War veterans

Gail D. Tillman, Timothy A. Green, Thomas C. Ferree, Clifford S. Calley, Mandy J. Maguire, Richard Briggs, John Hart, Robert W. Haley, Michael A. Kraut

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Poor performance on tasks requiring response inhibition has been observed among chronically ill veterans of the 1991 Persian Gulf War. Semantic difficulties have also been reported. We collected event-related potential (ERP) and behavioral data from 25 Gulf War veterans who complained of cognitive difficulties and from 23 matched controls, who were deployed but not symptomatic, while they performed a GO-NOGO task that required both a semantic decision and inhibitory processing. A significantly greater false-alarm rate among the ill veterans was accompanied in the ERP data by significantly reduced amplitude in the NOGO P3, consistent with previous ERP studies of other patient groups that have shown poor inhibitory response performance. This supports the contention that the ill veterans' deficit lies more in inhibiting than in detecting task-related differences in the stimuli.

Original language	English (US)
Pages (from-to)	1-5
Number of pages	5
Journal	Journal of the Neurological Sciences
Volume	297
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jns.2010.07.021
State	Published - Oct 15 2010

Keywords

Basal ganglia
ERP
Frontal lobe
GO-NOGO
Gulf War Illness
N2-P3
Semantic

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1016/j.jns.2010.07.021

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title = "Impaired response inhibition in ill Gulf War veterans",

abstract = "Poor performance on tasks requiring response inhibition has been observed among chronically ill veterans of the 1991 Persian Gulf War. Semantic difficulties have also been reported. We collected event-related potential (ERP) and behavioral data from 25 Gulf War veterans who complained of cognitive difficulties and from 23 matched controls, who were deployed but not symptomatic, while they performed a GO-NOGO task that required both a semantic decision and inhibitory processing. A significantly greater false-alarm rate among the ill veterans was accompanied in the ERP data by significantly reduced amplitude in the NOGO P3, consistent with previous ERP studies of other patient groups that have shown poor inhibitory response performance. This supports the contention that the ill veterans' deficit lies more in inhibiting than in detecting task-related differences in the stimuli.",

keywords = "Basal ganglia, ERP, Frontal lobe, GO-NOGO, Gulf War Illness, N2-P3, Semantic",

author = "Tillman, {Gail D.} and Green, {Timothy A.} and Ferree, {Thomas C.} and Calley, {Clifford S.} and Maguire, {Mandy J.} and Richard Briggs and John Hart and Haley, {Robert W.} and Kraut, {Michael A.}",

note = "Funding Information: This study was supported by IDIQ contract VA549-P-0027, awarded and administered by the Department of Veterans Affairs Medical Center, Dallas, TX, by DOD grant no. DAMD 17-01-1-0741 from the U.S. Army Medical Research and Materiel Command, and by NIH (NCRR) grant number UL1RR024982 . The content does not necessarily reflect the position or the policy of the Federal government or the sponsoring agencies, and no official endorsement should be inferred.",

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AU - Calley, Clifford S.

AU - Maguire, Mandy J.

AU - Briggs, Richard

AU - Hart, John

AU - Haley, Robert W.

AU - Kraut, Michael A.

N1 - Funding Information: This study was supported by IDIQ contract VA549-P-0027, awarded and administered by the Department of Veterans Affairs Medical Center, Dallas, TX, by DOD grant no. DAMD 17-01-1-0741 from the U.S. Army Medical Research and Materiel Command, and by NIH (NCRR) grant number UL1RR024982 . The content does not necessarily reflect the position or the policy of the Federal government or the sponsoring agencies, and no official endorsement should be inferred.

PY - 2010/10/15

Y1 - 2010/10/15

N2 - Poor performance on tasks requiring response inhibition has been observed among chronically ill veterans of the 1991 Persian Gulf War. Semantic difficulties have also been reported. We collected event-related potential (ERP) and behavioral data from 25 Gulf War veterans who complained of cognitive difficulties and from 23 matched controls, who were deployed but not symptomatic, while they performed a GO-NOGO task that required both a semantic decision and inhibitory processing. A significantly greater false-alarm rate among the ill veterans was accompanied in the ERP data by significantly reduced amplitude in the NOGO P3, consistent with previous ERP studies of other patient groups that have shown poor inhibitory response performance. This supports the contention that the ill veterans' deficit lies more in inhibiting than in detecting task-related differences in the stimuli.

AB - Poor performance on tasks requiring response inhibition has been observed among chronically ill veterans of the 1991 Persian Gulf War. Semantic difficulties have also been reported. We collected event-related potential (ERP) and behavioral data from 25 Gulf War veterans who complained of cognitive difficulties and from 23 matched controls, who were deployed but not symptomatic, while they performed a GO-NOGO task that required both a semantic decision and inhibitory processing. A significantly greater false-alarm rate among the ill veterans was accompanied in the ERP data by significantly reduced amplitude in the NOGO P3, consistent with previous ERP studies of other patient groups that have shown poor inhibitory response performance. This supports the contention that the ill veterans' deficit lies more in inhibiting than in detecting task-related differences in the stimuli.

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Impaired response inhibition in ill Gulf War veterans

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Keywords

ASJC Scopus subject areas

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