@article{166902c802b940729028b0ab7e370367,
title = "Impaired phonemic discrimination in logopenic variant primary progressive aphasia",
abstract = "Logopenic variant primary progressive aphasia (lvPPA) is the least well defined of the major primary progressive aphasia (PPA) syndromes. We assessed phoneme discrimination in patients with PPA (semantic, nonfluent/agrammatic, and logopenic variants) and typical Alzheimer{\textquoteright}s disease, relative to healthy age-matched participants. The lvPPA group performed significantly worse than all other groups apart from tAD, after adjusting for auditory verbal working memory. In the combined PPA cohort, voxel-based morphometry correlated phonemic discrimination score with grey matter in left angular gyrus. Our findings suggest that impaired phonemic discrimination may help differentiate lvPPA from other PPA subtypes, with important diagnostic and management implications.",
author = "Johnson, {Jeremy C.S.} and Jessica Jiang and Bond, {Rebecca L.} and Elia Benhamou and Requena-Komuro, {Ma{\"i} Carmen} and Russell, {Lucy L.} and Caroline Greaves and Annabel Nelson and Harri Sivasathiaseelan and Marshall, {Charles R.} and Volkmer, {Anna P.} and Rohrer, {Jonathan D.} and Warren, {Jason D.} and Hardy, {Chris J.D.}",
note = "Funding Information: The authors thank all the participants for their involvement. The Dementia Research Centre is supported by Alzheimer's Research UK, Brain Research Trust, and The Wolfson Foundation. This work was supported by the Alzheimer{\textquoteright}s Society (grant AS‐PG‐16‐007 to JDW), the National Institute for Health Research University College London Hospitals Biomedical Research Centre, the University College London Leonard Wolfson Experimental Neurology Centre (grant PR/ylr/18575), an Action on Hearing Loss–Dunhill Medical Trust Pauline Ashley Fellowship (grant PA23_Hardy to CJDH), a Medical Research Council PhD Studentship (RLB), a Medical Research Council Clinician Scientist Fellowship (JDR), an Association of British Neurologists‐Guarantors of Brain Clinical Research Training Fellowship (JCSJ) and Wolfson Foundation Clinical Research Fellowships (HS and CRM). Neuropsychological and MRI data were collected as part of the Longitudinal Investigation of Frontotemporal Dementia (LIFTD) study at University College London. Funding Information: The authors thank all the participants for their involvement. The Dementia Research Centre is supported by Alzheimer's Research UK, Brain Research Trust, and The Wolfson Foundation. This work was supported by the Alzheimer{\textquoteright}s Society (grant AS-PG-16-007 to JDW), the National Institute for Health Research University College London Hospitals Biomedical Research Centre, the University College London Leonard Wolfson Experimental Neurology Centre (grant PR/ylr/18575), an Action on Hearing Loss–Dunhill Medical Trust Pauline Ashley Fellowship (grant PA23_Hardy to CJDH), a Medical Research Council PhD Studentship (RLB), a Medical Research Council Clinician Scientist Fellowship (JDR), an Association of British Neurologists-Guarantors of Brain Clinical Research Training Fellowship (JCSJ) and Wolfson Foundation Clinical Research Fellowships (HS and CRM). Neuropsychological and MRI data were collected as part of the Longitudinal Investigation of Frontotemporal Dementia (LIFTD) study at University College London. Publisher Copyright: {\textcopyright} 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association",
year = "2020",
month = jul,
day = "1",
doi = "10.1002/acn3.51101",
language = "English (US)",
volume = "7",
pages = "1252--1257",
journal = "Annals of Clinical and Translational Neurology",
issn = "2328-9503",
publisher = "John Wiley and Sons Inc.",
number = "7",
}