Impaired phonemic discrimination in logopenic variant primary progressive aphasia

Jeremy C.S. Johnson, Jessica Jiang, Rebecca L. Bond, Elia Benhamou, Maï Carmen Requena-Komuro, Lucy L. Russell, Caroline Greaves, Annabel Nelson, Harri Sivasathiaseelan, Charles R. Marshall, Anna P. Volkmer, Jonathan D. Rohrer, Jason D. Warren, Chris J.D. Hardy

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Logopenic variant primary progressive aphasia (lvPPA) is the least well defined of the major primary progressive aphasia (PPA) syndromes. We assessed phoneme discrimination in patients with PPA (semantic, nonfluent/agrammatic, and logopenic variants) and typical Alzheimer’s disease, relative to healthy age-matched participants. The lvPPA group performed significantly worse than all other groups apart from tAD, after adjusting for auditory verbal working memory. In the combined PPA cohort, voxel-based morphometry correlated phonemic discrimination score with grey matter in left angular gyrus. Our findings suggest that impaired phonemic discrimination may help differentiate lvPPA from other PPA subtypes, with important diagnostic and management implications.

Original languageEnglish (US)
Pages (from-to)1252-1257
Number of pages6
JournalAnnals of Clinical and Translational Neurology
Issue number7
StatePublished - Jul 1 2020
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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