Impaired phonemic discrimination in logopenic variant primary progressive aphasia

Jeremy C.S. Johnson; Jessica Jiang; Rebecca L. Bond; Elia Benhamou; Maï Carmen Requena-Komuro; Lucy L. Russell; Caroline Greaves; Annabel Nelson; Harri Sivasathiaseelan; Charles R. Marshall; Anna P. Volkmer; Jonathan D. Rohrer; Jason D. Warren; Chris J.D. Hardy

doi:10.1002/acn3.51101

Impaired phonemic discrimination in logopenic variant primary progressive aphasia

Jeremy C.S. Johnson, Jessica Jiang, Rebecca L. Bond, Elia Benhamou, Maï Carmen Requena-Komuro, Lucy L. Russell, Caroline Greaves, Annabel Nelson, Harri Sivasathiaseelan, Charles R. Marshall, Anna P. Volkmer, Jonathan D. Rohrer, Jason D. Warren, Chris J.D. Hardy

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Logopenic variant primary progressive aphasia (lvPPA) is the least well defined of the major primary progressive aphasia (PPA) syndromes. We assessed phoneme discrimination in patients with PPA (semantic, nonfluent/agrammatic, and logopenic variants) and typical Alzheimer’s disease, relative to healthy age-matched participants. The lvPPA group performed significantly worse than all other groups apart from tAD, after adjusting for auditory verbal working memory. In the combined PPA cohort, voxel-based morphometry correlated phonemic discrimination score with grey matter in left angular gyrus. Our findings suggest that impaired phonemic discrimination may help differentiate lvPPA from other PPA subtypes, with important diagnostic and management implications.

Original language	English (US)
Pages (from-to)	1252-1257
Number of pages	6
Journal	Annals of Clinical and Translational Neurology
Volume	7
Issue number	7
DOIs	https://doi.org/10.1002/acn3.51101
State	Published - Jul 1 2020
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience
Clinical Neurology

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Johnson, J. C. S., Jiang, J., Bond, R. L., Benhamou, E., Requena-Komuro, M. C., Russell, L. L., Greaves, C., Nelson, A., Sivasathiaseelan, H., Marshall, C. R., Volkmer, A. P., Rohrer, J. D., Warren, J. D., & Hardy, C. J. D. (2020). Impaired phonemic discrimination in logopenic variant primary progressive aphasia. Annals of Clinical and Translational Neurology, 7(7), 1252-1257. https://doi.org/10.1002/acn3.51101

Johnson, JCS, Jiang, J, Bond, RL, Benhamou, E, Requena-Komuro, MC, Russell, LL, Greaves, C, Nelson, A, Sivasathiaseelan, H, Marshall, CR, Volkmer, AP, Rohrer, JD, Warren, JD & Hardy, CJD 2020, 'Impaired phonemic discrimination in logopenic variant primary progressive aphasia', Annals of Clinical and Translational Neurology, vol. 7, no. 7, pp. 1252-1257. https://doi.org/10.1002/acn3.51101

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title = "Impaired phonemic discrimination in logopenic variant primary progressive aphasia",

abstract = "Logopenic variant primary progressive aphasia (lvPPA) is the least well defined of the major primary progressive aphasia (PPA) syndromes. We assessed phoneme discrimination in patients with PPA (semantic, nonfluent/agrammatic, and logopenic variants) and typical Alzheimer{\textquoteright}s disease, relative to healthy age-matched participants. The lvPPA group performed significantly worse than all other groups apart from tAD, after adjusting for auditory verbal working memory. In the combined PPA cohort, voxel-based morphometry correlated phonemic discrimination score with grey matter in left angular gyrus. Our findings suggest that impaired phonemic discrimination may help differentiate lvPPA from other PPA subtypes, with important diagnostic and management implications.",

author = "Johnson, {Jeremy C.S.} and Jessica Jiang and Bond, {Rebecca L.} and Elia Benhamou and Requena-Komuro, {Ma{\"i} Carmen} and Russell, {Lucy L.} and Caroline Greaves and Annabel Nelson and Harri Sivasathiaseelan and Marshall, {Charles R.} and Volkmer, {Anna P.} and Rohrer, {Jonathan D.} and Warren, {Jason D.} and Hardy, {Chris J.D.}",

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AU - Johnson, Jeremy C.S.

AU - Jiang, Jessica

AU - Bond, Rebecca L.

AU - Benhamou, Elia

AU - Requena-Komuro, Maï Carmen

AU - Russell, Lucy L.

AU - Greaves, Caroline

AU - Nelson, Annabel

AU - Sivasathiaseelan, Harri

AU - Marshall, Charles R.

AU - Volkmer, Anna P.

AU - Rohrer, Jonathan D.

AU - Warren, Jason D.

AU - Hardy, Chris J.D.

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N2 - Logopenic variant primary progressive aphasia (lvPPA) is the least well defined of the major primary progressive aphasia (PPA) syndromes. We assessed phoneme discrimination in patients with PPA (semantic, nonfluent/agrammatic, and logopenic variants) and typical Alzheimer’s disease, relative to healthy age-matched participants. The lvPPA group performed significantly worse than all other groups apart from tAD, after adjusting for auditory verbal working memory. In the combined PPA cohort, voxel-based morphometry correlated phonemic discrimination score with grey matter in left angular gyrus. Our findings suggest that impaired phonemic discrimination may help differentiate lvPPA from other PPA subtypes, with important diagnostic and management implications.

AB - Logopenic variant primary progressive aphasia (lvPPA) is the least well defined of the major primary progressive aphasia (PPA) syndromes. We assessed phoneme discrimination in patients with PPA (semantic, nonfluent/agrammatic, and logopenic variants) and typical Alzheimer’s disease, relative to healthy age-matched participants. The lvPPA group performed significantly worse than all other groups apart from tAD, after adjusting for auditory verbal working memory. In the combined PPA cohort, voxel-based morphometry correlated phonemic discrimination score with grey matter in left angular gyrus. Our findings suggest that impaired phonemic discrimination may help differentiate lvPPA from other PPA subtypes, with important diagnostic and management implications.

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Impaired phonemic discrimination in logopenic variant primary progressive aphasia

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