Impact of statins on the coagulation status of type 2 diabetes patients evaluated by a novel thrombin-generation assay

P. Ferroni; D. Della-Morte; A. Pileggi; M. G. Valente; F. Martini; F. La Farina; R. Palmirotta; L. F. Meneghini; T. Rundek; C. Ricordi; F. Guadagni

doi:10.1007/s10557-012-6388-y

Impact of statins on the coagulation status of type 2 diabetes patients evaluated by a novel thrombin-generation assay

P. Ferroni, D. Della-Morte, A. Pileggi, M. G. Valente, F. Martini, F. La Farina, R. Palmirotta, L. F. Meneghini, T. Rundek, C. Ricordi, F. Guadagni

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12 Scopus citations

Abstract

Purpose Dyslipidemia is common in type 2 diabetes (T2D) and contributes to cardiovascular disease (CVD) by exacerbating atherosclerosis and hypercoagulability. Statins can stabilize atherosclerotic plaque and reduce prothrombotic status. In the present study we aimed to evaluate the coagulation activity and the effect of statins on procoagulant state of T2D patients using a novel activated protein C (APC)-dependent thrombin-generation assay. Methods Procoagulant status (by HemosIL ThromboPath (ThP) assay) and in vivo platelet activation (by plasma soluble (s)CD40L levels) were analyzed in a retrospective, cross-sectional study of 198 patients with long-standing T2D and 198 controls. Results Procoagulant status of T2D patients was enhanced when compared to control subjects (p<0.0001). Similarly, sCD40L levels were increased in T2D (p<0.0001). When testing ThP as the dependent variable in a multivariate regression model, sCD40L (p<0.0001) and statin treatment (p=0.019) were independent predictors of the procoagulant state of T2D patients. Subgroup analysis showed a significant improvement of coagulability in T2D patients on statins (p=0.012). Conclusions The use of a standardized, easy-to-run, and commercially available APC-dependent thrombin-generation assay detected the presence of a procoagulant status in a large series of patients with long-standing T2D and demonstrated a significant impact of statins in the coagulation status of patients with T2D.

Original language	English (US)
Pages (from-to)	301-309
Number of pages	9
Journal	Cardiovascular Drugs and Therapy
Volume	26
Issue number	4
DOIs	https://doi.org/10.1007/s10557-012-6388-y
State	Published - Aug 2012

Keywords

Dyslipidemia
Haemostasis
Lipid-Lowering Drugs
Type 2 Diabetes

ASJC Scopus subject areas

Pharmacology
Cardiology and Cardiovascular Medicine
Pharmacology (medical)

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10.1007/s10557-012-6388-y

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Ferroni, P., Della-Morte, D., Pileggi, A., Valente, M. G., Martini, F., La Farina, F., Palmirotta, R., Meneghini, L. F., Rundek, T., Ricordi, C., & Guadagni, F. (2012). Impact of statins on the coagulation status of type 2 diabetes patients evaluated by a novel thrombin-generation assay. Cardiovascular Drugs and Therapy, 26(4), 301-309. https://doi.org/10.1007/s10557-012-6388-y

Ferroni, P, Della-Morte, D, Pileggi, A, Valente, MG, Martini, F, La Farina, F, Palmirotta, R, Meneghini, LF, Rundek, T, Ricordi, C & Guadagni, F 2012, 'Impact of statins on the coagulation status of type 2 diabetes patients evaluated by a novel thrombin-generation assay', Cardiovascular Drugs and Therapy, vol. 26, no. 4, pp. 301-309. https://doi.org/10.1007/s10557-012-6388-y

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title = "Impact of statins on the coagulation status of type 2 diabetes patients evaluated by a novel thrombin-generation assay",

abstract = "Purpose Dyslipidemia is common in type 2 diabetes (T2D) and contributes to cardiovascular disease (CVD) by exacerbating atherosclerosis and hypercoagulability. Statins can stabilize atherosclerotic plaque and reduce prothrombotic status. In the present study we aimed to evaluate the coagulation activity and the effect of statins on procoagulant state of T2D patients using a novel activated protein C (APC)-dependent thrombin-generation assay. Methods Procoagulant status (by HemosIL ThromboPath (ThP) assay) and in vivo platelet activation (by plasma soluble (s)CD40L levels) were analyzed in a retrospective, cross-sectional study of 198 patients with long-standing T2D and 198 controls. Results Procoagulant status of T2D patients was enhanced when compared to control subjects (p<0.0001). Similarly, sCD40L levels were increased in T2D (p<0.0001). When testing ThP as the dependent variable in a multivariate regression model, sCD40L (p<0.0001) and statin treatment (p=0.019) were independent predictors of the procoagulant state of T2D patients. Subgroup analysis showed a significant improvement of coagulability in T2D patients on statins (p=0.012). Conclusions The use of a standardized, easy-to-run, and commercially available APC-dependent thrombin-generation assay detected the presence of a procoagulant status in a large series of patients with long-standing T2D and demonstrated a significant impact of statins in the coagulation status of patients with T2D.",

keywords = "Dyslipidemia, Haemostasis, Lipid-Lowering Drugs, Type 2 Diabetes",

author = "P. Ferroni and D. Della-Morte and A. Pileggi and Valente, {M. G.} and F. Martini and {La Farina}, F. and R. Palmirotta and Meneghini, {L. F.} and T. Rundek and C. Ricordi and F. Guadagni",

note = "Funding Information: Acknowledgments This work was partially supported by the Italian Ministry of Health Grant ACC-WP 3/1b and MERIT RBNE08NKH7. The authors wish to thank Francesco De Angelis and Vincenzino Perrone (InterInstitutional Multidisciplinary BioBank, Department of Laboratory Medicine and Advanced Biotechnologies, IRCCS San Raffaele, Rome, Italy), for their excellent technical assistance.",

year = "2012",

month = aug,

doi = "10.1007/s10557-012-6388-y",

language = "English (US)",

volume = "26",

pages = "301--309",

journal = "Cardiovascular Drugs and Therapy",

issn = "0920-3206",

publisher = "Kluwer Academic Publishers",

number = "4",

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TY - JOUR

T1 - Impact of statins on the coagulation status of type 2 diabetes patients evaluated by a novel thrombin-generation assay

AU - Ferroni, P.

AU - Della-Morte, D.

AU - Pileggi, A.

AU - Valente, M. G.

AU - Martini, F.

AU - La Farina, F.

AU - Palmirotta, R.

AU - Meneghini, L. F.

AU - Rundek, T.

AU - Ricordi, C.

AU - Guadagni, F.

N1 - Funding Information: Acknowledgments This work was partially supported by the Italian Ministry of Health Grant ACC-WP 3/1b and MERIT RBNE08NKH7. The authors wish to thank Francesco De Angelis and Vincenzino Perrone (InterInstitutional Multidisciplinary BioBank, Department of Laboratory Medicine and Advanced Biotechnologies, IRCCS San Raffaele, Rome, Italy), for their excellent technical assistance.

PY - 2012/8

Y1 - 2012/8

N2 - Purpose Dyslipidemia is common in type 2 diabetes (T2D) and contributes to cardiovascular disease (CVD) by exacerbating atherosclerosis and hypercoagulability. Statins can stabilize atherosclerotic plaque and reduce prothrombotic status. In the present study we aimed to evaluate the coagulation activity and the effect of statins on procoagulant state of T2D patients using a novel activated protein C (APC)-dependent thrombin-generation assay. Methods Procoagulant status (by HemosIL ThromboPath (ThP) assay) and in vivo platelet activation (by plasma soluble (s)CD40L levels) were analyzed in a retrospective, cross-sectional study of 198 patients with long-standing T2D and 198 controls. Results Procoagulant status of T2D patients was enhanced when compared to control subjects (p<0.0001). Similarly, sCD40L levels were increased in T2D (p<0.0001). When testing ThP as the dependent variable in a multivariate regression model, sCD40L (p<0.0001) and statin treatment (p=0.019) were independent predictors of the procoagulant state of T2D patients. Subgroup analysis showed a significant improvement of coagulability in T2D patients on statins (p=0.012). Conclusions The use of a standardized, easy-to-run, and commercially available APC-dependent thrombin-generation assay detected the presence of a procoagulant status in a large series of patients with long-standing T2D and demonstrated a significant impact of statins in the coagulation status of patients with T2D.

AB - Purpose Dyslipidemia is common in type 2 diabetes (T2D) and contributes to cardiovascular disease (CVD) by exacerbating atherosclerosis and hypercoagulability. Statins can stabilize atherosclerotic plaque and reduce prothrombotic status. In the present study we aimed to evaluate the coagulation activity and the effect of statins on procoagulant state of T2D patients using a novel activated protein C (APC)-dependent thrombin-generation assay. Methods Procoagulant status (by HemosIL ThromboPath (ThP) assay) and in vivo platelet activation (by plasma soluble (s)CD40L levels) were analyzed in a retrospective, cross-sectional study of 198 patients with long-standing T2D and 198 controls. Results Procoagulant status of T2D patients was enhanced when compared to control subjects (p<0.0001). Similarly, sCD40L levels were increased in T2D (p<0.0001). When testing ThP as the dependent variable in a multivariate regression model, sCD40L (p<0.0001) and statin treatment (p=0.019) were independent predictors of the procoagulant state of T2D patients. Subgroup analysis showed a significant improvement of coagulability in T2D patients on statins (p=0.012). Conclusions The use of a standardized, easy-to-run, and commercially available APC-dependent thrombin-generation assay detected the presence of a procoagulant status in a large series of patients with long-standing T2D and demonstrated a significant impact of statins in the coagulation status of patients with T2D.

KW - Dyslipidemia

KW - Haemostasis

KW - Lipid-Lowering Drugs

KW - Type 2 Diabetes

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Impact of statins on the coagulation status of type 2 diabetes patients evaluated by a novel thrombin-generation assay

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