Impact of mtor-i on fertility and pregnancy: State of the art and review of the literature

Marialuisa Framarino-Dei-Malatesta, Martina Derme, Tommaso M. Manzia, Giuseppe Iaria, Linda De Luca, Laura Fazzolari, Angela Napoli, Pasquale Berloco, Timil Patel, Giuseppe Orlando, Giuseppe Tisone

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations


Successful transplantation should lead to improvements in sexual function and sex hormone disturbances in both men and women, but immunosuppressive drugs may interfere with hormone metabolism. In this regard, several studies have showed a potential negative effect of mTOR inhibitors (mTORi) on male gonadal function, while their role in the female patients is not well documented in the literature. Successful pregnancy is possible after solid organ transplantation. The fetal effects of mTORi are still poorly defined but they seem not to represent an absolute contraindication for pregnancy. The aim of our study would be to review the impact of mTORi on fertility and pregnancy in order to have a clearer picture about their possible use after organ transplantation.

Original languageEnglish (US)
Pages (from-to)781-789
Number of pages9
JournalExpert review of clinical immunology
Issue number8
StatePublished - Aug 2013


  • fertility
  • immunosuppression
  • kidney transplant8mTORi
  • pregnancy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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