TY - JOUR
T1 - Impact of moderate physical activity on the longitudinal trajectory of a cardiac specific biomarker of injury
T2 - Results from a randomized pilot study of exercise intervention
AU - deFilippi, Christopher R.
AU - de Lemos, James A
AU - Newman, Anne B.
AU - Guralnik, Jack M.
AU - Christenson, Robert H.
AU - Pahor, Marco
AU - Church, Timothy
AU - Espeland, Mark
AU - Krithevsky, Stephen B.
AU - Stafford, Randall
AU - Seliger, Stephen L.
N1 - Funding Information:
The LIFE-P study was funded by a grant from the National Institutes of Health/National Institute on Aging ( U01 AG22376 ) and supported in part by the Intramural Research Program, National Institute on Aging. The measurement of hs-cTnT was funded by an investigator-initiated grant (deFilippi) from Roche Diagnostics .
Publisher Copyright:
© 2016 Elsevier, Inc.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - In animal models, physical activity (PA) prevents cardiac myocyte cell death. Data for PA mitigating myocyte injury in humans are limited to observational studies. Using a randomized controlled trial design, we sought to determine if introducing moderate PA to previously sedentary older adults could reduce the trajectory of myocardial injury as measured by the high-sensitive cardiac troponin T (hs-cTnT) assay. Methods Participants (age ≥70 years) were assigned to a 1-year intervention of moderate PA or health education control. High-sensitive cTnT was measured at baseline and 1 year in the 307 of 424 subjects who had available stored serum. Changes in hs-cTnT within 1 year were compared between PA and control groups, as were differences in the proportion of subjects with a significant rise in hs-cTnT (prospectively defined as a>50% increase at follow-up from baseline). Moderate to vigorous PA in kcal/wk was estimated with the CHAMPS questionnaire. Results Baseline hs-cTnT levels and PA kcal/wk were similar for both groups. Activity kcal/wk increased in the PA, but not in the control group at 1 year. The median increase in hs-cTnT level from baseline was >3 times larger in the control (0.73 ng/L, interquartile range −0.64 to 2.59) vs the PA group (0.19ng/L, interquartile range −1.10 to 1.93) (P=.02). The proportion with a>50% increase in hs-cTnT was larger in the control group than in the PA group (9.3% vs 5.1%), but this difference was not statistically significant (P=.16). Conclusions Initiation of moderate PA in sedentary older adults may favorably modify subclinical myocardial injury.
AB - In animal models, physical activity (PA) prevents cardiac myocyte cell death. Data for PA mitigating myocyte injury in humans are limited to observational studies. Using a randomized controlled trial design, we sought to determine if introducing moderate PA to previously sedentary older adults could reduce the trajectory of myocardial injury as measured by the high-sensitive cardiac troponin T (hs-cTnT) assay. Methods Participants (age ≥70 years) were assigned to a 1-year intervention of moderate PA or health education control. High-sensitive cTnT was measured at baseline and 1 year in the 307 of 424 subjects who had available stored serum. Changes in hs-cTnT within 1 year were compared between PA and control groups, as were differences in the proportion of subjects with a significant rise in hs-cTnT (prospectively defined as a>50% increase at follow-up from baseline). Moderate to vigorous PA in kcal/wk was estimated with the CHAMPS questionnaire. Results Baseline hs-cTnT levels and PA kcal/wk were similar for both groups. Activity kcal/wk increased in the PA, but not in the control group at 1 year. The median increase in hs-cTnT level from baseline was >3 times larger in the control (0.73 ng/L, interquartile range −0.64 to 2.59) vs the PA group (0.19ng/L, interquartile range −1.10 to 1.93) (P=.02). The proportion with a>50% increase in hs-cTnT was larger in the control group than in the PA group (9.3% vs 5.1%), but this difference was not statistically significant (P=.16). Conclusions Initiation of moderate PA in sedentary older adults may favorably modify subclinical myocardial injury.
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U2 - 10.1016/j.ahj.2016.07.001
DO - 10.1016/j.ahj.2016.07.001
M3 - Article
C2 - 27595690
AN - SCOPUS:84979085630
SN - 0002-8703
VL - 179
SP - 151
EP - 156
JO - American heart journal
JF - American heart journal
ER -