Impact of erythrocytapheresis on natural anticoagulant levels in children with sickle cell disease: A pilot study

Ruchika Sharma; Gary M. Woods; Susan Creary; Sarah O'Brien; Joseph Stanek; Kan Hor; Christina Gallagher; Amy L. Dunn; Riten Kumar

doi:10.1002/pbc.27588

Impact of erythrocytapheresis on natural anticoagulant levels in children with sickle cell disease: A pilot study

Ruchika Sharma, Gary M. Woods, Susan Creary, Sarah O'Brien, Joseph Stanek, Kan Hor, Christina Gallagher, Amy L. Dunn, Riten Kumar

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Venous thromboembolism (VTE) is being increasingly recognized in children with sickle cell disease (SCD). In a retrospective cohort study, we identified bilateral central venous catheter (CVC) placement as an independent risk factor for VTE. At our institution, the only indication for bilateral CVC placement in children with SCD is erythrocytapheresis. To investigate the impact of erythrocytapheresis on coagulation, we measured levels of natural anticoagulants in 11 patients with SCD on chronic erythrocytapheresis, immediately before and after apheresis. We demonstrated a statistically significant reduction in most parameters. Additional studies are needed to further investigate the exact etiology and clinical impact of this acute decrease.

Original language	English (US)
Article number	e27588
Journal	Pediatric Blood and Cancer
Volume	66
Issue number	4
DOIs	https://doi.org/10.1002/pbc.27588
State	Published - Apr 2019
Externally published	Yes

Keywords

erythrocytapheresis
natural anticoagulants
sickle cell disease
venous thrombosis

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

Access to Document

10.1002/pbc.27588

Cite this

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title = "Impact of erythrocytapheresis on natural anticoagulant levels in children with sickle cell disease: A pilot study",

abstract = "Venous thromboembolism (VTE) is being increasingly recognized in children with sickle cell disease (SCD). In a retrospective cohort study, we identified bilateral central venous catheter (CVC) placement as an independent risk factor for VTE. At our institution, the only indication for bilateral CVC placement in children with SCD is erythrocytapheresis. To investigate the impact of erythrocytapheresis on coagulation, we measured levels of natural anticoagulants in 11 patients with SCD on chronic erythrocytapheresis, immediately before and after apheresis. We demonstrated a statistically significant reduction in most parameters. Additional studies are needed to further investigate the exact etiology and clinical impact of this acute decrease.",

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T2 - A pilot study

AU - Sharma, Ruchika

AU - Woods, Gary M.

AU - Creary, Susan

AU - O'Brien, Sarah

AU - Stanek, Joseph

AU - Hor, Kan

AU - Gallagher, Christina

AU - Dunn, Amy L.

AU - Kumar, Riten

PY - 2019/4

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AB - Venous thromboembolism (VTE) is being increasingly recognized in children with sickle cell disease (SCD). In a retrospective cohort study, we identified bilateral central venous catheter (CVC) placement as an independent risk factor for VTE. At our institution, the only indication for bilateral CVC placement in children with SCD is erythrocytapheresis. To investigate the impact of erythrocytapheresis on coagulation, we measured levels of natural anticoagulants in 11 patients with SCD on chronic erythrocytapheresis, immediately before and after apheresis. We demonstrated a statistically significant reduction in most parameters. Additional studies are needed to further investigate the exact etiology and clinical impact of this acute decrease.

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Impact of erythrocytapheresis on natural anticoagulant levels in children with sickle cell disease: A pilot study

Abstract

Keywords

ASJC Scopus subject areas

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