Immunogenicity of novel consensus-based DNA vaccines against avian influenza

Dominick J. Laddy; Jian Yan; Natasha Corbitt; Darwyn Kobasa; Gary P. Kobinger; David B. Weiner

doi:10.1016/j.vaccine.2007.01.063

Immunogenicity of novel consensus-based DNA vaccines against avian influenza

Dominick J. Laddy, Jian Yan, Natasha Corbitt, Darwyn Kobasa, Gary P. Kobinger, David B. Weiner

Research output: Contribution to journal › Article › peer-review

107 Scopus citations

Abstract

The frequency of H5N1 avian influenza outbreaks in China and Eastern Europe has raised concern in the world health community regarding the potential for an influenza pandemic. Efforts to monitor the disease will only provide minimal warning in a global society, and steps must be taken to prevent the morbidity and mortality associated with past pandemics. The current stockpiling of antibody-inducing "bird flu" vaccines assumes the strain that emerges will be the same as strains currently circulating. We propose a novel consensus-based approach to vaccine development, employing a DNA vaccine strategy that can provide more highly cross-reactive cellular immunity against lethal influenza infection. We show such constructs can induce strong cellular immunity against H5 influenza antigens.

Original language	English (US)
Pages (from-to)	2984-2989
Number of pages	6
Journal	Vaccine
Volume	25
Issue number	16 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.vaccine.2007.01.063
State	Published - Apr 20 2007
Externally published	Yes

Keywords

Avian influenza
Consensus
DNA vaccine

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

Access to Document

10.1016/j.vaccine.2007.01.063

Cite this

@article{b3d19b289fc54b19b4fbce6318fc75e9,

title = "Immunogenicity of novel consensus-based DNA vaccines against avian influenza",

abstract = "The frequency of H5N1 avian influenza outbreaks in China and Eastern Europe has raised concern in the world health community regarding the potential for an influenza pandemic. Efforts to monitor the disease will only provide minimal warning in a global society, and steps must be taken to prevent the morbidity and mortality associated with past pandemics. The current stockpiling of antibody-inducing {"}bird flu{"} vaccines assumes the strain that emerges will be the same as strains currently circulating. We propose a novel consensus-based approach to vaccine development, employing a DNA vaccine strategy that can provide more highly cross-reactive cellular immunity against lethal influenza infection. We show such constructs can induce strong cellular immunity against H5 influenza antigens.",

keywords = "Avian influenza, Consensus, DNA vaccine",

author = "Laddy, {Dominick J.} and Jian Yan and Natasha Corbitt and Darwyn Kobasa and Kobinger, {Gary P.} and Weiner, {David B.}",

note = "Funding Information: Vaccine studies were supported by grants from NIH to D.B.W. Challenges were supported by G.P.K. ",

year = "2007",

month = apr,

day = "20",

doi = "10.1016/j.vaccine.2007.01.063",

language = "English (US)",

volume = "25",

pages = "2984--2989",

journal = "Vaccine",

issn = "0264-410X",

publisher = "Elsevier BV",

number = "16 SPEC. ISS.",

}

TY - JOUR

T1 - Immunogenicity of novel consensus-based DNA vaccines against avian influenza

AU - Laddy, Dominick J.

AU - Yan, Jian

AU - Corbitt, Natasha

AU - Kobasa, Darwyn

AU - Kobinger, Gary P.

AU - Weiner, David B.

N1 - Funding Information: Vaccine studies were supported by grants from NIH to D.B.W. Challenges were supported by G.P.K.

PY - 2007/4/20

Y1 - 2007/4/20

N2 - The frequency of H5N1 avian influenza outbreaks in China and Eastern Europe has raised concern in the world health community regarding the potential for an influenza pandemic. Efforts to monitor the disease will only provide minimal warning in a global society, and steps must be taken to prevent the morbidity and mortality associated with past pandemics. The current stockpiling of antibody-inducing "bird flu" vaccines assumes the strain that emerges will be the same as strains currently circulating. We propose a novel consensus-based approach to vaccine development, employing a DNA vaccine strategy that can provide more highly cross-reactive cellular immunity against lethal influenza infection. We show such constructs can induce strong cellular immunity against H5 influenza antigens.

AB - The frequency of H5N1 avian influenza outbreaks in China and Eastern Europe has raised concern in the world health community regarding the potential for an influenza pandemic. Efforts to monitor the disease will only provide minimal warning in a global society, and steps must be taken to prevent the morbidity and mortality associated with past pandemics. The current stockpiling of antibody-inducing "bird flu" vaccines assumes the strain that emerges will be the same as strains currently circulating. We propose a novel consensus-based approach to vaccine development, employing a DNA vaccine strategy that can provide more highly cross-reactive cellular immunity against lethal influenza infection. We show such constructs can induce strong cellular immunity against H5 influenza antigens.

KW - Avian influenza

KW - Consensus

KW - DNA vaccine

UR - http://www.scopus.com/inward/record.url?scp=33947604318&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33947604318&partnerID=8YFLogxK

U2 - 10.1016/j.vaccine.2007.01.063

DO - 10.1016/j.vaccine.2007.01.063

M3 - Article

C2 - 17306909

AN - SCOPUS:33947604318

SN - 0264-410X

VL - 25

SP - 2984

EP - 2989

JO - Vaccine

JF - Vaccine

IS - 16 SPEC. ISS.

ER -

Immunogenicity of novel consensus-based DNA vaccines against avian influenza

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this