TY - GEN
T1 - Imaging system design for surgical guidance with near-infrared autofluorescence
AU - McWade, Melanie
AU - Pence, Isaac J.
AU - Paras, Constantine
AU - Mahadevan-Jansen, Anita
N1 - Publisher Copyright:
© 2015 SPIE.
PY - 2015
Y1 - 2015
N2 - We present a study to evaluate and compare three near-infrared (NIR) fluorescence imaging systems designed to provide intraoperative guidance around anatomical structures. The three systems adapted specifically for the application of endogenous NIR fluorescence detection were (1) a photomultiplier tube based NIR viewer, (2) a thermoelectrically cooled electron-multiplying charge-coupled device (CCD) camera, and (3) a clinical endoscope CCD camera system. Each system was evaluated on the basis of ease-of-use, cost, and system performance. The cooled CCD camera showed the highest contrast ratio, but is limited in utility by its bulk interface and high cost. The clinical endoscope camera showed flexibility in its field-of-view and provides the benefit of being sterilized to allow easy integration into the surgical suite; however, it exhibits signal nonlinearity that would distort quantitative analysis. The NIR viewer shows optimal performance, exhibiting high spatial resolution, linearity, and sufficient contrast to differentiate between tissue types. This low-cost design proves to be the optimal system for parathyroid detection, offering ease-of-use in a surgical setting while meeting system performance requirements.
AB - We present a study to evaluate and compare three near-infrared (NIR) fluorescence imaging systems designed to provide intraoperative guidance around anatomical structures. The three systems adapted specifically for the application of endogenous NIR fluorescence detection were (1) a photomultiplier tube based NIR viewer, (2) a thermoelectrically cooled electron-multiplying charge-coupled device (CCD) camera, and (3) a clinical endoscope CCD camera system. Each system was evaluated on the basis of ease-of-use, cost, and system performance. The cooled CCD camera showed the highest contrast ratio, but is limited in utility by its bulk interface and high cost. The clinical endoscope camera showed flexibility in its field-of-view and provides the benefit of being sterilized to allow easy integration into the surgical suite; however, it exhibits signal nonlinearity that would distort quantitative analysis. The NIR viewer shows optimal performance, exhibiting high spatial resolution, linearity, and sufficient contrast to differentiate between tissue types. This low-cost design proves to be the optimal system for parathyroid detection, offering ease-of-use in a surgical setting while meeting system performance requirements.
KW - anatomical imaging
KW - intraoperative imaging
KW - near-infrared fluorescence
KW - parathyroid detection
KW - surgical guidance
UR - http://www.scopus.com/inward/record.url?scp=84925679114&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84925679114&partnerID=8YFLogxK
U2 - 10.1117/12.2076632
DO - 10.1117/12.2076632
M3 - Conference contribution
AN - SCOPUS:84925679114
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII
A2 - Vo-Dinh, Tuan
A2 - Mahadevan-Jansen, Anita
A2 - Grundfest, Warren S.
PB - SPIE
T2 - Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIII
Y2 - 8 February 2015 through 10 February 2015
ER -