@inproceedings{e25616ef5c4c4680859ce0f8c4499604,
title = "Imaging-genetic data mapping for clinical outcome prediction via supervised conditional Gaussian graphical model",
abstract = "Imaging-genetic data mapping is important for clinical outcome prediction like survival analysis. In this paper, we propose a supervised conditional Gaussian graphical model (SuperCGGM) to uncover survival associated mapping between pathological images and genetic data. The proposed method integrates heterogeneous modal data into the survival model by weighted projection within the data. To obtain a sparse solution, we employ l-1 regularization to the partial log likelihood loss function and propose a cyclic coordinate ascent algorithm to solve it. It also gives a way to bridge the gap between the supervised model with conditional Gaussian graphical model (CGGM). Compared to nine state-of-the-art methods like SuperPCA, CGGM, etc., our method is superior due to its ability of integrating diverse information from heterogeneous modal data in a supervised way. The extensive experiments also show the strong power of SuperCGGM in mapping survival associated image and gene expression signatures.",
keywords = "CGGM, Data mapping, Imaging-genetic, Survival analysis",
author = "Xinliang Zhu and Jiawen Yao and Guanghua Xiao and Yang Xie and Jaime Rodriguez-Canales and Parra, {Edwin R.} and Carmen Behrens and Wistuba, {Ignacio I.} and Junzhou Huang",
note = "Publisher Copyright: {\textcopyright} 2016 IEEE.; 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016 ; Conference date: 15-12-2016 Through 18-12-2016",
year = "2017",
month = jan,
day = "17",
doi = "10.1109/BIBM.2016.7822559",
language = "English (US)",
series = "Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "455--459",
editor = "Kevin Burrage and Qian Zhu and Yunlong Liu and Tianhai Tian and Yadong Wang and Hu, {Xiaohua Tony} and Qinghua Jiang and Jiangning Song and Shinichi Morishita and Kevin Burrage and Guohua Wang",
booktitle = "Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016",
}