@article{09fd06d20df84e0284d335b0192b23b9,
title = "Identification of new markers for the Schistosoma mansoni vitelline lineage",
abstract = "Schistosomes cause significant morbidity and mortality in millions of the world's poorest people. While parasite egg-induced inflammation is the primary driver of host pathology, relatively little is known at the molecular level about the organ systems that participate in schistosome egg production (i.e., testes, ovaries and vitellaria). Here we use transcriptional profiling and in situ hybridization to characterise the vitellarium of Schistosoma mansoni. We uncovered several previously uncharacterised vitellaria-specific factors and defined molecular markers for various stages in the vitellocyte differentiation process. These data provide the framework for future in-depth molecular studies exploring the biology of this important parasite organ.",
keywords = "Reproduciton, Schistosoma, Stem cell, Vitellaria",
author = "Jipeng Wang and Collins, {James J.}",
note = "Funding Information: We thank Julie Collins, George Wendt and Anushka Wikramarante for comments on the manuscript. This work was supported by National Institutes of Health (NIH), USA, R01AI121037 (JJC) and the Wellcome Trust , United Kingdom, grant number 107475/Z/15/Z . Mice and B . glabrata snails were provided by the National Institutes for Allergy and Infectious Disease Schistosomiasis Resource Center of the Biomedical Research Institute (Rockville, MD, USA) through NIH-NIAID Contract HHSN272201000005I for distribution through BEI Resources. In adherence to the Animal Welfare Act and the Public Health Service Policy on Humane Care and Use of Laboratory Animals, all experiments with and care of vertebrate animals were performed in accordance with protocols approved by the Institutional Animal Care and Use Committee (IACUC) of University of Texas Southwestern Medical Center, USA (protocol approval number APN 2014-0072). The RNAseq dataset is available at NCBI under the accession number GSE78967. Publisher Copyright: {\textcopyright} 2016 The Authors.",
year = "2016",
month = jun,
day = "1",
doi = "10.1016/j.ijpara.2016.03.004",
language = "English (US)",
volume = "46",
pages = "405--410",
journal = "International Journal for Parasitology",
issn = "0020-7519",
publisher = "Elsevier Limited",
number = "7",
}